{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:19:18Z","timestamp":1775582358469,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":3660,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>Seirogan, an herbal medicine containing wood creosote (CAS 8021\u201039\u20104), a mixture of simple phenolic compounds, has been marketed for the past century in Asia for the treatment of acute diarrhea and associated symptoms, such as abdominal discomfort and cramping. The present study was designed to assess the safety and tolerability of an anticipated acute antidiarrheal dosing regimen. Sixty healthy males were randomized into five groups of 12 subjects each (9 wood creosote; 3 placebo) to receive 45\u2010, 90\u2010, 135\u2010, 180\u2010, and 225\u2010mg tablets every 2 hours for five doses. Serial sitting and standing vital signs, ECG rhythm strips, and continuous telemetry monitoring were obtained predose and for 24 hours after the first dose. Clinical laboratory tests and 12\u2010lead resting ECGs were obtained predose and 24 hours postdose. Of the subjects, 27% (12\/45) receiving wood creosote and 27% (4\/15) receiving placebo reported adverse events. The most common adverse events were altered taste and somnolence, reported more often with 180\u2010 and 225\u2010mg doses. Wood creosote had no clinically significant effects on vital signs, ECG intervals or interpretations, or clinical laboratory tests. No clinically significant or serious dysrhythmias were reported on continuous telemetry monitoring. It was concluded that oral doses of wood creosote 45 to 225 mg every 2 hours for up to five doses were safe and well tolerated in 45 healthy subjects. Wood creosote doses ranging from 45 to 135 mg per dose, which are commonly administered antidiarrheal doses in Asia, were associated with minimal side effects.<\/jats:p>","DOI":"10.1177\/0091270002250606","type":"journal-article","created":{"date-parts":[[2003,4,28]],"date-time":"2003-04-28T10:30:40Z","timestamp":1051525840000},"page":"284-290","source":"Crossref","is-referenced-by-count":11,"title":["Multiple\u2010Dose Escalation, Safety, and Tolerability Study of Wood Creosote, the Principal Active Ingredient of Seirogan, an Herbal Antidiarrheal Medication, in Healthy Subjects"],"prefix":"10.1002","volume":"43","author":[{"given":"Tomoo","family":"Kuge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Willett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"issue":"9","key":"e_1_2_5_2_2","first-page":"502","article-title":"Creosote: a short history of its medicinal uses","volume":"54","author":"Haller JS","year":"1990","journal-title":"Conn Med"},{"key":"e_1_2_5_3_2","first-page":"411","article-title":"Analysis of beech wood creosote by gas chromatography\u2010mass spectrometry and high performance liquid chromatography","volume":"66","author":"Ogata N","year":"1989","journal-title":"Res Commun ChemPathol Pharmacol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/109158101753253036"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00443.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.23.952"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000056092"},{"key":"e_1_2_5_8_2","article-title":"Safety and pharmacokinetic study of wood creosote, the principal active ingredient of Seirogan\u00ae","author":"Kuge T","journal-title":"Pharmacotherapy"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F0091270002250606","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0091270002250606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:53:56Z","timestamp":1697234036000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/0091270002250606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1177\/0091270002250606"],"URL":"https:\/\/doi.org\/10.1177\/0091270002250606","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}