{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:32:23Z","timestamp":1780446743729,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":3233,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p>Etanercept, a soluble recombinant human tumor necrosis factor receptor (TNFr) fusion protein, is effective and well tolerated in the treatment of rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). The primary objective of this study was to investigate the potential pharmacokinetic and pharmacodynamic interaction between a single dose of Rand S\u2010enantiomers of warfarin and multiple doses of etanercept after administration of warfarin and etanercept alone and together. In a nonrandomized, three\u2010period study, 12 healthy male subjects received a single oral 25\u2010mg dose of warfarin after an overnight fast, followed by twice\u2010weekly 25\u2010mg subcutaneous doses of etanercept for seven doses. The last dose of etanercept was administered concurrently with a second dose of warfarin. Serial blood samples for plasma warfarin concentration measurement and international normalized ratio (INR) assessment were collected before and up to 144 hours after dose administration. Serial blood samples for serum etanercept concentration measurement were collected before and up to 60 hours after the sixth dose and 264 hours after the seventh dose. Etanercept did not affect the pharmacokinetics and pharmacodynamics of warfarin. All ratios of maximum serum concentration (C<jats:sub><jats:italic>max<\/jats:italic><\/jats:sub>) and area under the serum concentration versus time curve (AUC) for pharmacokinetics (R\u2010 and S\u2010enantiomers of warfarin) and INR fell within the confidence interval of 0.8 to 1.25. Warfarin also did not cause a clinically significant alteration in the pharmacokinetics of etanercept. In conclusion, coadministration of etanercept and warfarin would not be expected to change the pharmacokinetics of either medication; therefore, no dosage adjustment is needed in cases in which warfarin and etanercept are coadministered.<\/jats:p>","DOI":"10.1177\/0091270004264164","type":"journal-article","created":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T16:53:25Z","timestamp":1082566405000},"page":"543-550","source":"Crossref","is-referenced-by-count":32,"title":["Absence of a Pharmacokinetic Interaction between Etanercept and Warfarin"],"prefix":"10.1002","volume":"44","author":[{"given":"Honghui","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Patat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Parks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Buckwalter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Metzger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Korth\u2010Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200262170-00013"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"6602","DOI":"10.4049\/jimmunol.151.11.6602","article-title":"The influence of a recombinant human soluble tumor necrosis factor receptor Fc fusion protein on type II collagen\u2010induced arthritis in mice","volume":"151","author":"Wooley PH","year":"1993","journal-title":"J Immunol"},{"issue":"5","key":"e_1_2_5_4_2","first-page":"1118","article-title":"Absolute bioavailability of TNF receptor fusion protein following subcutaneous injection in healthy volunteers [abstract 233]","volume":"17","author":"Lebsack ME","year":"1997","journal-title":"Pharmacotherapy"},{"key":"e_1_2_5_5_2","unstructured":"European Agency for Evaluation of Medicinal Products:Scientific discussion: Enbrel[online]. 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