{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:43:08Z","timestamp":1792204988553,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":3141,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p>The pharmacokinetics of a meloxicam suspension were studied in 18 children with juvenile rheumatoid arthritis. Children received a single 0.25\u2010mg\/kg dose up to a maximum of 15 mg. Pharmacokinetic parameters after the first dose were calculated by noncompartmental methods. Geometric mean (percent coefficient of variation for geometric mean [gCV]) C<jats:sub><jats:italic>max<\/jats:italic><\/jats:sub>, AUC<jats:sub><jats:italic>0\u2010\u221e<\/jats:italic><\/jats:sub>, apparent clearance, apparent volume of distribution, and elimination half\u2010life values were 1.24 \u03bcg\/mL (47% gCV), 25.6 \u03bcg\u2022h\/mL (81% gCV), 0.17 mL\/min\/kg (83% gCV), 0.19 L\/kg (63% gCV), and 13.4 hours (54% gCV) in the younger group and 1.89 \u03bcg\/mL (25% gCV), 35.8 \u03bcg\u2022h\/mL (21% gCV), 0.12 mL\/min\/kg (23% gCV), 0.13 L\/kg (22% gCV), and 12.7 hours (21% gCV) for the older group, respectively. Area under the curve, volume of distribution, and clearance tended to be higher in the younger group, whereas elimination half\u2010lives were similar. A post hoc comparison to pharmacokinetic data in adults revealed no relevant differences. Thus, a common body weight\u2013normalized dose is considered appropriate for children older than 2 years.<\/jats:p>","DOI":"10.1177\/0091270004267589","type":"journal-article","created":{"date-parts":[[2004,7,15]],"date-time":"2004-07-15T01:32:39Z","timestamp":1089855159000},"page":"866-872","source":"Crossref","is-referenced-by-count":22,"title":["Pharmacokinetics of Meloxicam in Patients With Juvenile Rheumatoid 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