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Median total trough concentrations were 1.16\u20132.90 mcg\/mL. Unbound AUC<jats:sub>0\u201012<\/jats:sub> was 412\u2013673 ng\u2022h\/mL and did not change over time (P = .30). Median percent unbound mycophenolic acid was 0.95% of total concentrations. Individual unbound and total mycophenolic acid concentrations were highly correlated (r<jats:sup>2<\/jats:sup> = 0.94). Total mycophenolic acid trough concentration and total AUC<jats:sub>0\u201012<\/jats:sub> were modestly correlated (r<jats:sup>2<\/jats:sup> = 0.65). Intra\u2010 and interpatient variability of systemic mycophenolic acid exposure was high. Six patients required dose reductions prior to day 60 due to adverse effects. All subjects achieved insulin independence; 3 later lost graft function. 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