{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:41:38Z","timestamp":1697175698045},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T00:00:00Z","timestamp":1363651200000},"content-version":"vor","delay-in-days":2787,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p>The effect of pentosan polysulfate sodium on warfarin pharmacokinetics and pharmacodynamics was investigated in healthy subjects. Warfarin was titrated to an international normalized ratio between 1.4 and 1.8. Subjects continued their titrated dose of warfarin and received pentosan polysulfate sodium 100 mg or placebo every 8 hours for 7 days. The C<jats:sub>max<\/jats:sub> of R\u2010 and S\u2010warfarin was \u223c840 to 890 ng\/mL and 680 to 730 ng\/mL, respectively, and was similar in the absence and presence of pentosan polysulfate sodium. The half\u2010life for R\u2010 and S\u2010warfarin was 52 to 56 hours and 36 to 40 hours, respectively. Prothrombin time, partial thromboplastin time, and the international normalized ratio for warfarin + placebo and warfarin + pentosan polysulfate sodium were comparable. The AUC<jats:sub>INR<\/jats:sub> indicated no treatment effect (P = .772); however, there was a period effect. Analysis of variance for the treatments by period indicated no treatment effect (P &gt; .1). Adverse events were mild and included headache, epistaxis, and rash. Most adverse events were unrelated to treatment and were seen during warfarin titration. Pentosan polysulfate sodium did not affect warfarin pharmacokinetics or pharmacodynamics.<\/jats:p>","DOI":"10.1177\/0091270005278600","type":"journal-article","created":{"date-parts":[[2005,7,18]],"date-time":"2005-07-18T21:03:28Z","timestamp":1121720608000},"page":"919-926","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetics and Pharmacodynamics of Warfarin When Coadministered With Pentosan Polysulfate Sodium"],"prefix":"10.1002","volume":"45","author":[{"given":"Nishit B.","family":"Modi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherron","family":"Kell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012288145-9\/50101-7"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0094-0143(21)00587-5","article-title":"Epidemiology of interstitial cystitis","volume":"21","author":"Koziol JA","year":"1994","journal-title":"Urol Clin North Am"},{"key":"e_1_2_5_4_2","first-page":"165","volume-title":"Interstitial Cystitis","author":"Miller JL","year":"1997"},{"key":"e_1_2_5_5_2","first-page":"559","article-title":"Prevention of postoperative thromboembolic complications: a prospective comparison between Dextran 70, Dihydroergostamin heparin and a sulphated polysaccharide","volume":"146","author":"Bergqvist D","year":"1980","journal-title":"Acta Chir Scand"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800680702"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-2444-5_26"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(80)90018-3"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-72399-5_69"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050577"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/cpt1974162348","article-title":"Studies on the optical entiomorphs of warfarin in man","volume":"6","author":"O'Reilly RA","year":"1974","journal-title":"Clin Pharmacol Ther"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107711"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197108262850905"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197109022851005"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.4_Supplement.231S"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106273242606"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01068419"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1201\/b14095"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1993.164"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2001.01358.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2002.01587.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-9-199411010-00009"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(95)00158-1"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02635.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9236(95)90179-5"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2002.01616.x"},{"key":"e_1_2_5_27_2","first-page":"111","article-title":"Experimental studies on the anticoagulant and antithrombotic effects of sodium and calcium pentosan polysulfate","volume":"50","author":"Giedroj\u0107 J","year":"1999","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199909000-00004"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F0091270005278600","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0091270005278600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:21:15Z","timestamp":1697156475000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/0091270005278600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1177\/0091270005278600"],"URL":"https:\/\/doi.org\/10.1177\/0091270005278600","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}