{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:15:55Z","timestamp":1792433755808,"version":"4.5.0"},"reference-count":98,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":2654,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:italic>Danshen, the dried root of<\/jats:italic> Salvia miltiorrhiza, <jats:italic>has been widely used in China and, to a lesser extent, in Japan, the United States, and other European countries for the treatment of cardiovascular and cerebrovascular diseases. In China, the specific clinical use is angina pectoris, hyperlipidemia, and acute ischemic stroke. The current review covers its traditional uses, chemical constituents, pharmacological activities, pharmacokinetics, clinical applications, and potential herb\u2010drug interactions based on information obtained in both the English and Chinese literature. Although numerous clinical trials have demonstrated that certain Danshen products in China are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality. Therefore, large randomized clinical trials and further scientific research to determine its mechanism of actions will be necessary to ensure the safety, effectiveness, and better understanding of its action<\/jats:italic>.<\/jats:p>","DOI":"10.1177\/0091270005282630","type":"journal-article","created":{"date-parts":[[2005,11,15]],"date-time":"2005-11-15T19:02:48Z","timestamp":1132081368000},"page":"1345-1359","source":"Crossref","is-referenced-by-count":1132,"title":["Danshen: An Overview of Its Chemistry, Pharmacology, Pharmacokinetics, and Clinical Use"],"prefix":"10.1002","volume":"45","author":[{"given":"Limin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses Sing Sum","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_10_2_2","first-page":"24","article-title":"Clinical observation of the treatment of hyperlipemia with Danshen composite","volume":"15","author":"Ma JY.","year":"1998","journal-title":"Tianjin Zhongyi"},{"key":"e_1_2_10_3_2","first-page":"671","article-title":"Clinical observation of the treatment of 60 hyperlipaemia with Fufang Danshen Dripping Pill","volume":"22","author":"Wu XY","year":"2000","journal-title":"Hebei Zhongyi"},{"key":"e_1_2_10_4_2","first-page":"47","article-title":"Effect of Danshen composite on hyperlipaemia and blood rheology","volume":"17","author":"Ma WY","year":"2001","journal-title":"Jiefangjun Yaoxue Xuebao"},{"key":"e_1_2_10_5_2","first-page":"1029","article-title":"Clinical effect of Fufang Danshen Dripping Pill on hyperlipemia","volume":"11","author":"Cui SK","year":"2003","journal-title":"Xiandai Zhongxiyi Jiehe Zazhi"},{"key":"e_1_2_10_6_2","first-page":"49","article-title":"Clinical observation of Danshen composite on cerebral infarction","volume":"17","author":"Mao JM","year":"2001","journal-title":"Jiefangjun Yaoxue Xuebao"},{"key":"e_1_2_10_7_2","first-page":"124","article-title":"Clinical investigation of composite Danshen Dripping Pill for the treatment of angina pectoris","volume":"1","author":"Guo ZX","year":"2003","journal-title":"Zhongguo Tianran Yaowu"},{"key":"e_1_2_10_8_2","first-page":"474","article-title":"Research advance of Fufang Danshen dosage forms","volume":"12","author":"Liu XQ","year":"2001","journal-title":"Shizhen Guoyi Guoyao"},{"key":"e_1_2_10_9_2","first-page":"54","article-title":"An investigation of Danshen root: pharmacology study, clinical application and preparation","volume":"2","author":"Hu XR","year":"2003","journal-title":"Zhongguo Xinyiyao"},{"key":"e_1_2_10_10_2","first-page":"872","article-title":"Review of research on pharmacopoeia prescription preparation of compound salvia","volume":"24","author":"Ge YR","year":"2002","journal-title":"Zhong Cheng Yao"},{"key":"e_1_2_10_11_2","first-page":"461","article-title":"Study on tanshinone rapid soluble tablet","volume":"5","author":"Hu RF","year":"2002","journal-title":"Zhongguo Yaoshi"},{"key":"e_1_2_10_12_2","first-page":"32","article-title":"Study on the preparation of tanshinone preliposomes by spray drying method","volume":"37","author":"Chu MQ","year":"2002","journal-title":"Zhongguo Yaoxue Zazhi"},{"key":"e_1_2_10_13_2","first-page":"191","article-title":"Study on solid dispersion of tanshinone","volume":"27","author":"Chu MQ","year":"2001","journal-title":"Huadong Ligong Daxue Xuebao"},{"key":"e_1_2_10_14_2","volume-title":"Pharmacopoeia of the People's Republic of China Version 2005","author":"The Pharmacopoeia Commission of PRC.","year":"2005"},{"key":"e_1_2_10_15_2","unstructured":"Tianjin Talisco Pharmaceutical Group Co. 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