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For comparison, we identified other elderly patients hospitalized with acute myocardial infarction (N = 4491), fracture (N = 2797), or pneumonia (N = 9473). The categories of medications included drugs that affect the cardiovascular, central nervous, or the muscular skeletal system. The most notable differences between syncope compared to acute myocardial infarction patients occurred in central nervous system drugs in anticonvulsants\/barbiturates, antidepressants, antihistamine\/antinauseants, antipsychotics, and cholinesterase inhibitors (<jats:italic>P<\/jats:italic> &lt; .0018). Comparing syncope patients with fracture patients, the central nervous medication profile was similar, but the cardiovascular medication profile differed (<jats:italic>P<\/jats:italic> &lt; .0018); their hypertension comorbidities also differed (60.45% vs 46.34%); (<jats:italic>P<\/jats:italic> &lt; .0016). These findings indicate significant potential associations that warrant further study. Studies linking national outpatient medications to hospitalizations for specific conditions can foster the development of more proactive pharmacovigilance systems.<\/jats:p>","DOI":"10.1177\/0091270006288452","type":"journal-article","created":{"date-parts":[[2006,5,17]],"date-time":"2006-05-17T01:24:04Z","timestamp":1147829044000},"page":"613-619","source":"Crossref","is-referenced-by-count":4,"title":["National Veterans Health Administration Hospitalizations for Syncope Compared to Acute Myocardial Infarction, Fracture, or Pneumonia in Community\u2010Dwelling Elders: Outpatient Medication and Comorbidity Profiles"],"prefix":"10.1002","volume":"46","author":[{"given":"Dustin D.","family":"French","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Spehar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence Z.","family":"Rubenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Accomando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.22.2716"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53402.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.15.1621"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.3.305"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)06119-4"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2001.49115.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200522100-00006"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200528120-00008"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.967"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb01898.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb01899.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199812010-00005"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"989","DOI":"10.7326\/0003-4819-126-12-199706150-00012","article-title":"Diagnosing syncope, 1: value of history, physical examination, and electrocardiography","volume":"126","author":"Linzer M","year":"1997","journal-title":"Ann Intern Med."},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.7326\/0003-4819-127-1-199707010-00014","article-title":"Diagnosing syncope, 2: unexplained syncope","volume":"127","author":"Linzer M","year":"1997","journal-title":"Ann Intern Med."},{"key":"e_1_2_6_16_2","first-page":"1492","article-title":"Evaluation of syncope","volume":"72","author":"Miller TH","year":"2005","journal-title":"Am Fam Physician [serial online]"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2001.114838"},{"key":"e_1_2_6_18_2","first-page":"34","article-title":"Investigating syncope: a review","volume":"21","author":"Gould PA","year":"2006","journal-title":"Curr Opin Cardiol."},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2003.12.002"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4943(02)00003-1"},{"key":"e_1_2_6_21_2","unstructured":"Healthcare Cost and Utilization Project. 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