{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:38:26Z","timestamp":1759541906578},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":2411,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>Intravenous lidocaine, a nonspecific Na\u2010channel blocker, was used to assess the dental impaction model for evaluation of neuropathic pain drugs. Sixty patients, experiencing moderate or severe pain after removal of \u2265 2 third molars, were randomized (2:2:1:1) to lidocaine (4 mg\/kg; maximal dose 300 mg), oxycodone\/acetaminophen (10\/650 mg), placebo, and active placebo (diphenhydramine, 50 mg). Lidocaine provided a modest degree of pain relief. Predefined endpoints of total pain relief and sum of pain intensity at 2, 4, and 6 hours showed numerically, not statistically significantly, greater pain relief versus placebo. A significantly greater effect over placebo was observed in peak effect and at shorter time points (30 minutes and 1 hour), consistent with the pharmacokinetic profile (plasma concentration of \u223c2 \u03bcg\/mL). Oxycodone\/acetaminophen provided significantly greater analgesia versus placebo, validating study conduct, and significantly greater pain relief was observed versus lidocaine, which is consistent with a smaller portion of dental extraction pain being of neuropathic origin.<\/jats:p>","DOI":"10.1177\/0091270006289847","type":"journal-article","created":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T17:28:28Z","timestamp":1153330108000},"page":"917-924","source":"Crossref","is-referenced-by-count":5,"title":["Dental Impaction Pain Model as a Potential Tool to Evaluate Drugs With Efficacy in Neuropathic Pain"],"prefix":"10.1002","volume":"46","author":[{"given":"Kerstin","family":"Malmstrom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Kotey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"McGratty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohini","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Gottesdiener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alise","family":"Reicin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00233-6"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-5712(94)90084-1"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198510000-00005"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/54.5.501"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200204000-00010"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00229-3"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199601000-00016"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)02980-6"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200108000-00022"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(89)90109-7"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/eujp.2001.0235"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199706000-00006"},{"key":"e_1_2_5_14_2","first-page":"534","article-title":"Intravenous lidocaine, amantadine, and placebo in the treatment of sciatica: a double\u2010blind, randomized, controlled study","volume":"24","author":"Medrick\u2010Goldberg T","year":"1999","journal-title":"Regional Anesth Pain Med."}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F0091270006289847","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0091270006289847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:50:31Z","timestamp":1697460631000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/0091270006289847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1177\/0091270006289847"],"URL":"https:\/\/doi.org\/10.1177\/0091270006289847","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}