{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:45:12Z","timestamp":1790905512505,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":2257,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>Recently, a new latanoprost ophthalmic solution containing cyclodextrins was developed. The purpose of the present work was to compare the stability, clinical efficacy, and adverse effect profile of this formulation with the innovator product. The innovator formulation was stable at 4\u00b0C but exhibited degradation at higher temperatures, whereas the cyclodextrin\u2010containing formulation was stable at temperatures up to 40\u00b0C. Formulations were assayed in a randomized double\u2010blind clinical study in patients with primary open\u2010angle glaucoma and\/or ocular hypertension. Both latanoprost ophthalmic solutions produced comparable reduction of intraocular pressure. Conjunctival hyperemia was observed in 11.9% and 11.3% of the patients treated with the innovator and the cyclodextrin\u2010containing formulations, respectively. There were no significant differences between the 2 ophthalmic solutions in efficacy or in the measured adverse effect. It is concluded that these 2 latanoprost ophthalmic solutions yield comparable efficacy and adverse effect outcomes. The cyclodextrin\u2010containing formulation, however, has an improved stability.<\/jats:p>","DOI":"10.1177\/0091270006292626","type":"journal-article","created":{"date-parts":[[2006,12,27]],"date-time":"2006-12-27T20:42:54Z","timestamp":1167252174000},"page":"121-126","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of the Stability, Efficacy, and Adverse Effect Profile of the Innovator 0.005% Latanoprost Ophthalmic Solution and a Novel Cyclodextrin\u2010containing Formulation"],"prefix":"10.1002","volume":"47","author":[{"given":"Jaime R.","family":"Gonzalez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldo","family":"Baiza\u2010Duran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Quintana\u2010Hau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Tornero\u2010Monta\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Castaneda\u2010Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Alarcon\u2010Oceguera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Beltran\u2010Loustaunau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cortez\u2010Gastelum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Garcidue\u00f1as\u2010Mejia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Gomez\u2010Bastar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Jimenez\u2010Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Korder\u2010Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Paczka\u2010Zapata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Torres\u2010Segura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Velasco\u2010Gallegos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76171-9"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810293391808"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.6.701"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.1.48"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01437-9"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713688109001850"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)80003-3"},{"key":"e_1_2_7_9_2","first-page":"1474","article-title":"The effect of prostaglandin F2 alpha on intraocular pressure in normotensive human subjects","volume":"29","author":"Lee PY","year":"1988","journal-title":"Invest Ophtalmol Vis Sci."},{"key":"e_1_2_7_10_2","first-page":"1134","article-title":"From PGF(2alpha)\u2010isopropyl ester to latanoprost: a review of the development of Xalatan: the Proctor Lecture","volume":"42","author":"Stjernschantz JW","year":"2001","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/112067210301300208"},{"key":"e_1_2_7_12_2","first-page":"745","article-title":"The pharmacokinetics of a new antiglaucoma drug, latanoprost, in the rabbit","volume":"26","author":"Sjoquist B","year":"1998","journal-title":"Drug Metab Dispos."},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(02)00302-8"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31484-3"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200110000-00007"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.08.017"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/js950534b"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(01)00761-X"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2002.800205.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.02.058"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01257-0"},{"key":"e_1_2_7_22_2","volume-title":"Principles and Procedures of Statistics. A Biometrical Approach","author":"Steel RGD","year":"1997"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1367"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200320080-00005"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F0091270006292626","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0091270006292626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T19:42:05Z","timestamp":1697139725000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/0091270006292626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1177\/0091270006292626"],"URL":"https:\/\/doi.org\/10.1177\/0091270006292626","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}