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Ten healthy male volunteers were enrolled, and 8 subjects completed this single\u2010dose, open\u2010label, randomized, 5\u2010way crossover study. Forty milligrams of fasudil HCl was administered as solution to the distal ileum and ascending colon, as powder to the ascending colon, and orally as an immediate\u2010release tablet and solution. All treatments were well\u2010tolerated and no serious adverse events were observed. The mean systemic availabilities of M3 relative to the oral solution were 1.04 (distal ileum, solution), 1.14 (ascending colon, solution), 1.27 (ascending colon, powder) and 1.04 (oral tablet), indicating similar systemic availability of M3 after administration of fasudil HCl to different gastrointestinal sites. The results suggest that development of a once\u2010a\u2010day extended\u2010release formulation for fasudil HCl should be readily achievable.<\/jats:p>","DOI":"10.1177\/0091270006293767","type":"journal-article","created":{"date-parts":[[2006,12,27]],"date-time":"2006-12-27T20:42:54Z","timestamp":1167252174000},"page":"19-25","source":"Crossref","is-referenced-by-count":26,"title":["Systemic Availability of the Active Metabolite Hydroxy\u2010Fasudil After Administration of Fasudil to Different Sites of the Human Gastrointestinal Tract"],"prefix":"10.1002","volume":"47","author":[{"given":"Peter H.","family":"Hinderling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel 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