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Dapoxetine was rapidly absorbed and eliminated; peak concentrations were noted 1.47 hours after administration and decreased with an alpha half\u2010life of 1.33 hours and a terminal half\u2010life of 15.6 hours. Pharmacokinetic parameters (C<jats:sub><jats:italic>max<\/jats:italic><\/jats:sub>, AUC<jats:sub>\u221e<\/jats:sub>, t<jats:sub><jats:italic>1\/2<\/jats:italic><\/jats:sub>, and t<jats:sub><jats:italic>max<\/jats:italic><\/jats:sub>) of dapoxetine were not altered with concurrent ethanol consumption. Furthermore, coadministration of dapoxetine did not affect the pharmacokinetics of ethanol or potentiate the cognitive and subjective effects of ethanol.<\/jats:p>","DOI":"10.1177\/0091270006297229","type":"journal-article","created":{"date-parts":[[2007,2,23]],"date-time":"2007-02-23T00:58:44Z","timestamp":1172192324000},"page":"315-322","source":"Crossref","is-referenced-by-count":15,"title":["Dapoxetine Has No Pharmacokinetic or Cognitive Interactions With Ethanol in Healthy Male Volunteers"],"prefix":"10.1002","volume":"47","author":[{"given":"Nishit B.","family":"Modi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Dresser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhaval","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Edgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Wesnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.6.537"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2004.04033.x"},{"issue":"1","key":"e_1_2_6_4_2","first-page":"57","article-title":"The premature ejaculation prevalence and attitudes (PEPA) survey: a multi\u2010national survey","volume":"1","author":"Rosen R","year":"2004","journal-title":"J Sex Med."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000132159.61156.ea"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(99)00048-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/00926239708403923"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199808000-00004"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270005284850"},{"key":"e_1_2_6_10_2","unstructured":"Centers for Disease Control and Prevention (CDC) National Center for Health Statistics National Health Interview Survey 1997\u20132002. 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