{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:09:12Z","timestamp":1793156952421,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":2107,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>This study examined the pharmacokinetics of fentanyl in burned patients during the hyperdynamic phase. Twenty adults, aged 37 \u00b1 2 years (mean \u00b1 SE), with 49 \u00b1 3% total body surface area burn, were studied at 17 \u00b1 2 days after the injury and compared to demographically matched controls. After a 200\u2010\u03bcg IV bolus of fentanyl, blood samples (n = 20) were collected for 4.5 hours. Concentration\u2010time curves were fitted to a 2\u2010compartment model. Burned patients had a higher cardiac index. Median fentanyl clearance (CL, 21.0 vs 29.4 mL\/kg\/min), central compartment volume (V<jats:sub>1<\/jats:sub>, 0.37 vs 0.61 L\/kg), and total volume of distribution (V<jats:sub>area<\/jats:sub>, 3.6 vs 5.8 L\/kg) were higher in burned patients. Cardiac index was unrelated to CL. The increased V<jats:sub>1<\/jats:sub> and V<jats:sub>area<\/jats:sub> are likely due to large intravenous fluid replacement and tissue edema. Higher CL and larger V<jats:sub>1<\/jats:sub> and V<jats:sub>area<\/jats:sub> leading to a lower fentanyl plasma concentration may partially explain the increased opiate requirement previously observed after burn injury.<\/jats:p>","DOI":"10.1177\/0091270007299756","type":"journal-article","created":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T17:51:20Z","timestamp":1179942680000},"page":"674-680","source":"Crossref","is-referenced-by-count":47,"title":["Fentanyl Clearance and Volume of Distribution Are Increased in Patients With Major Burns"],"prefix":"10.1002","volume":"47","author":[{"given":"Taehyung","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerold S.","family":"Harmatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Greenblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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