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Because gastric emptying affects oral medication absorption, this placebo\u2010controlled, single\u2010blind, crossover study examined the absorption of 1000 mg of acetaminophen elixir administered \u22122, \u22121, 0, +1, and +2 hours relative to pramlintide (120 \u03bcg) or 0 hours relative to placebo in 24 patients with type 2 diabetes. When acetaminophen administration occurred 0, +1, or +2 hours relative to pramlintide, the maximum observed plasma concentration of acetaminophen decreased 14% to 29%, and time to maximum observed plasma concentration increased by 0.8 to 1.2 hours compared with administration 0 hours relative to placebo. Pramlintide treatment slowed but did not alter the extent of acetaminophen absorption (area under the concentration\u2010time curve). No serious adverse events or withdrawals were reported. Oral agents should be administered at least 1 hour before or 2 hours after pramlintide injection if rapid onset of action is required for efficacy.<\/jats:p>","DOI":"10.1177\/0091270007300949","type":"journal-article","created":{"date-parts":[[2007,6,20]],"date-time":"2007-06-20T21:08:51Z","timestamp":1182373731000},"page":"798-805","source":"Crossref","is-referenced-by-count":14,"title":["Pharmacokinetics of an Oral Drug (Acetaminophen) Administered at Various Times Relative to Subcutaneous Injection of Pramlintide in Subjects With Type 2 Diabetes"],"prefix":"10.1002","volume":"47","author":[{"given":"Terrie A.","family":"Kellmeyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C.","family":"Kesty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan 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