{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:00:17Z","timestamp":1761512417765},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":2076,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>The sore throat pain model was employed in this randomized, placebo\u2010controlled trial to examine the sensitivity of the model in testing the efficacy of valdecoxib as an acute analgesic drug. Changes were made to the study design by employing a different diagnostic index for tonsillo\u2010pharyngitis, a different rating scale (derived from Lasagna's pain thermometer), and alternative analyses, individual responder rates. Under double\u2010blind conditions, 197 patients with painful pharyngitis were randomly allocated to valdecoxib 20 mg bid (n = 65), valdecoxib 40 mg qd (n = 66), or placebo (n = 66) for 24 hours. The expanded Tonsillo\u2010Pharyngitis Assessment and the Lasagna Pain Scale were validated as sensitive study instruments. Both dosage regimens provided significantly greater pain relief compared with placebo on standard efficacy measures over the 24\u2010hour study (all P &lt; .05). Tests for individual response (eg, percentage of patients with at least moderate relief) confirmed these results, and other response rates identified the high sensitivity of the model itself (eg, only 5% of placebo\u2010treated patients achieved \u226550% of maximum total pain relief over 6 hours). These findings indicate that sore throat is a sensitive model to assess analgesic efficacy.<\/jats:p>","DOI":"10.1177\/0091270007301621","type":"journal-article","created":{"date-parts":[[2007,6,20]],"date-time":"2007-06-20T21:11:22Z","timestamp":1182373882000},"page":"860-870","source":"Crossref","is-referenced-by-count":19,"title":["Utility and Sensitivity of the Sore Throat Pain Model: Results of a Randomized Controlled Trial on the COX\u20102 Selective Inhibitor Valdecoxib"],"prefix":"10.1002","volume":"47","author":[{"given":"Bernard P.","family":"Schachtel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D.","family":"Kohles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Sanner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily P.","family":"Schachtel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Bey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Towards Earlier Diagnosis in Primary Care","author":"Hodgkin K.","year":"1978"},{"key":"e_1_2_5_3_2","volume-title":"ICPC: International Classification of Primary Care","author":"Lamberts H","year":"1987"},{"key":"e_1_2_5_4_2","first-page":"1465","article-title":"Pharyngitis","volume":"69","author":"Vincent MT","year":"2004","journal-title":"Am Fam Physician"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1988.215"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1984.154"},{"key":"e_1_2_5_7_2","volume-title":"Advances in Pain Research and Therapy","author":"Schachtel BP.","year":"1991"},{"key":"e_1_2_5_8_2","volume-title":"Advances in Pain Research and Therapy","author":"Beaver WT.","year":"1983"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1960.tb42788.x"},{"issue":"10","key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1002\/cncr.1984.53.s10.2260","article-title":"Measurement of pain and analgesia in cancer patients","volume":"53","author":"Wallenstein SL.","year":"1984","journal-title":"Cancer"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1989.tb03273.x"},{"key":"e_1_2_5_12_2","first-page":"846","article-title":"Ibuprofen 400 mg compared to acetaminophen 600 mg with codeine 60 mg for pain relief following periodontal surgery","volume":"30","author":"Schachtel BP","year":"1990","journal-title":"J Clin Pharm"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400040081017"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1994.56"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.124079"},{"key":"e_1_2_5_16_2","first-page":"188","article-title":"Sensory qualities of pain in the evaluation of sore throat","volume":"47","author":"Konerman HJ","year":"1990","journal-title":"Clin Pharmacol Ther"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80308-7"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1993.75"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.1996.83"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-199917010-00001"},{"key":"e_1_2_5_21_2","first-page":"189","article-title":"Efficacy and safety of the anti\u2010inflammatory throat lozenge flurbiprofen 8.75 mg in the treatment of sore throat","volume":"13","author":"Benrimoj SI","year":"1999","journal-title":"Fundam Clin Pharmacol"},{"key":"e_1_2_5_22_2","first-page":"490","article-title":"Relief of sore throat with the anti\u2010inflammatory throat lozenge flurbiprofen 8.75 mg:a randomised, double\u2010blind, placebo\u2010controlled study of efficacy and safety","volume":"54","author":"Watson N","year":"2000","journal-title":"Int J Clin Pharm"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/147323000203000212"},{"key":"e_1_2_5_24_2","volume-title":"CDER OTC Analgesic Policy Change","author":"Food and Drug Administration, Department of Health and Human Services Public Health Service.","year":"1994"},{"key":"e_1_2_5_25_2","unstructured":"European Agency for the Evaluation of Medicinal Products (EMEA).Note for guidance on clinical investigation of medicinal products for treatment of nociceptive pain. 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