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In vitro study has demonstrated that cinacalcet is a potent inhibitor of cytochrome P450 (CYP) 2D6 with a K<jats:sub>i<\/jats:sub>value of 0.087 \u03bcmol\/L, which is comparable to the well\u2010known potent CYP2D6 inhibitor, quinidine (0.064 \u03bcmol\/L). A clinical study was conducted to assess the inhibitory effect of cinacalcet on CYP2D6 substrates in healthy volunteers. Each subject received 50 mg of cinacalcet or a matched placebo orally once daily for 8 days with 30 mg of dextromethorphan coadministered on day 8. The mean AUC<jats:sub>0\u2010\u221e<\/jats:sub>and C<jats:sub>max<\/jats:sub>of dextromethorphan increased 11\u2010 and 7\u2010fold, respectively, in extensive metabolizers when coadministered with cinacalcet versus placebo. 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