{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:01:23Z","timestamp":1789066883038,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":1923,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>This was a double\u2010blind, placebo\u2010controlled, randomized, 5\u2010period crossover study in 49 healthy subjects with a history of light (occasional) recreational stimulant use, to evaluate the abuse\u2010related subjective effects of oral osmotic\u2010controlled extended\u2010release methylphenidate with comparable doses of immediate\u2010release methylphenidate. Healthy subjects with a history of light recreational stimulant use were enrolled in the study if they demonstrated a positive response to a 20\u2010mg dose of d\u2010amphetamine and a negative placebo response. Enrolled subjects received single doses of placebo, 54 and 108 mg osmotic\u2010controlled extended\u2010release methylphenidate, and 50 and 90 mg immediate\u2010release methylphenidate. For each treatment, pharmacokinetics, pharmacodynamics, and safety were assessed for 24 hours. Subjective data were collected through standard questionnaires and visual analog scales for positive, stimulant, negative, and other effects. Immediate\u2010release and osmotic\u2010controlled extended\u2010release methylphenidate produced expected plasma concentration\u2010time profiles of d\u2010methylphenidate. Both doses of immediate\u2010release methylphenidate (50 and 90 mg) produced statistically significantly higher subjective effects (eg, positive, stimulant) with respect to placebo for all measures. The higher osmotic\u2010controlled extended\u2010release methylphenidate dose of 108 mg also produced statistically significant differences from placebo for most measures. However, the most commonly prescribed therapeutic dose of osmotic\u2010controlled extended\u2010release methylphenidate (54 mg) did not produce significant differences from placebo for most measures. In addition, for comparable dose levels, osmotic\u2010controlled extended\u2010release methylphenidate produced lower positive and stimulant subjective effects than immediate\u2010release methylphenidate, and low\u2010dose immediate\u2010release methylphenidate (50 mg) produced greater subjective effects than high\u2010dose osmotic\u2010controlled extended\u2010release methylphenidate, with many effects demonstrating statistically significant differences. These data support the hypothesis that a formulation can modulate abuse potential by controlling the rate and extent of drug delivery.<\/jats:p>","DOI":"10.1177\/0091270007308615","type":"journal-article","created":{"date-parts":[[2007,10,25]],"date-time":"2007-10-25T23:36:17Z","timestamp":1193355377000},"page":"1476-1488","source":"Crossref","is-referenced-by-count":47,"title":["Assessment of Pharmacokinetics and Pharmacodynamic Effects Related to Abuse Potential of a Unique Oral Osmotic\u2010Controlled Extended\u2010Release Methylphenidate Formulation in Humans"],"prefix":"10.1002","volume":"47","author":[{"given":"Doll A.","family":"Parasrampuria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerr A.","family":"Schoedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Schuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Ciccone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve A.","family":"Silber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwar M.","family":"Sellers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.5.1158"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"26S","DOI":"10.1097\/00004583-200202001-00003","article-title":"Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults","volume":"41","author":"Greenhill LL","year":"2002","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(02)00053-4"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/026988110001400107"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200002000-00011"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.9.1.59"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200106000-00005"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.9.1.59"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200106000-00005"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881104047281"},{"issue":"1","key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1177\/070674370200601S09","article-title":"Methylphenidate and substance abuse: a review of pharmacology, animal, and clinical studies","volume":"6","author":"Huss M","year":"2002","journal-title":"J Atten Disord"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00464-6"},{"issue":"11","key":"e_1_2_6_14_2","first-page":"14","article-title":"Comparing the abuse potential of methylphenidate versus other stimulants: a review of available evidence and relevance to the ADHD patient","volume":"64","author":"Kollins SH","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1086-5802(16)30473-9"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.11.1909"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/10550490490483053"},{"key":"e_1_2_6_18_2","volume-title":"Results From the 2004 National Survey on Drug Use and Health: National Findings","author":"US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration","year":"2004"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198611020-00004"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01754.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.6.4.367"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(03)00097-8"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(03)00098-X"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.01.015"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1971122part1245"},{"key":"e_1_2_6_26_2","first-page":"69","article-title":"Assessment of the abuse liability of buspirone in recreational sedative users","volume":"43","author":"Cole JO","year":"1982","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-199302000-00001"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.4.1.97"},{"key":"e_1_2_6_29_2","unstructured":"ParasrampuriaDA SchoedelKA SchullerR et al.Abuse potential of OROS methylphenidate versus immediate\u2010release methylphenidate and placebo. Poster presented at the 25th Annual Meeting of the American Academy of Child and Adolescent Psychiatry; October 18\u201323 2005; Toronto Ontario Canada."},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.3.387"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199901)31:1<59::AID-SYN8>3.0.CO;2-Y"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(02)00104-9"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.3.359"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2003.08.013"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199602000-00012"},{"key":"e_1_2_6_36_2","first-page":"247","article-title":"Smoked and intravenous cocaine in humans: acute tolerance, cardiovascular and subjective effects","volume":"257","author":"Foltin RW","year":"1991","journal-title":"J Pharmacol Exp Ther."},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199108000-00007"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-199712000-00009"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050358"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-199712000-00002"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00433062"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F0091270007308615","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0091270007308615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T14:36:52Z","timestamp":1697121412000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/0091270007308615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1177\/0091270007308615"],"URL":"https:\/\/doi.org\/10.1177\/0091270007308615","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}