{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:47:16Z","timestamp":1780580836025,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":1832,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p>The relative bioavailability of oral lisdexamfetamine dimesylate, a prodrug of d\u2010amphetamine, and active d\u2010amphetamine was assessed in an open\u2010label, single\u2010dose, 3\u2010treatment, 3\u2010period, randomized, crossover study in 18 healthy adult volunteers. Following a fast of at least 10 hours, subjects were administered an intact capsule of 70 mg lisdexamfetamine, a solution containing the capsule contents, or an intact capsule with a high\u2010fat meal. Standard meals started 4 hours following lisdexamfetamine administration. Blood samples were taken predose (0 hours) and 0.5 to 72 hours postdose, and the concentrations of d\u2010amphetamine and lisdexamfetamine were measured. AUC and C<jats:sub><jats:italic>max<\/jats:italic><\/jats:sub> for d\u2010amphetamine were similar when lisdexamfetamine 70 mg was administered to healthy adults in the fed or fasted state. The AUC of intact lisdexamfetamine was similar when the latter was taken without food or in solution, but C<jats:sub><jats:italic>max<\/jats:italic><\/jats:sub> was lower when lisdexamfetamine was administered with food. The t<jats:sub><jats:italic>max<\/jats:italic><\/jats:sub> of d\u2010amphetamine and intact lisdexamfetamine was similar when taken in solution or in the fasted state but was about 1 hour longer when taken with food. Adverse events were typical for amphetamine products. These findings indicate that food does not have a significant effect on d\u2010amphetamine or lisdexamfetamine bioavailability in healthy adults and that lisdexamfetamine was well tolerated.<\/jats:p>","DOI":"10.1177\/0091270007310381","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T03:44:33Z","timestamp":1203479073000},"page":"293-302","source":"Crossref","is-referenced-by-count":63,"title":["Relative Bioavailability of Lisdexamfetamine 70\u2010mg Capsules in Fasted and Fed Healthy Adult Volunteers and in Solution: A Single\u2010Dose, Crossover Pharmacokinetic Study"],"prefix":"10.1002","volume":"48","author":[{"given":"Suma","family":"Krishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.14.1100"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200404000-00020"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.12.1281.32697"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-4993(18)30136-6"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2003.9.5.416"},{"key":"e_1_2_5_7_2","first-page":"83","article-title":"Welcome progress in the diagnosis and treatment of ADHD in adolescence","volume":"20","author":"Stein MA","year":"2003","journal-title":"Contemp Pediatr"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(07)80083-X"},{"key":"e_1_2_5_9_2","unstructured":"KrishnanS.A multiple\u2010dose single\u2010arm pharmacokinetics study of oral lisdexamfetamine (LDX; NRP104) in healthy adult volunteers. Abstract presented at: New Clinical Drug Evaluation Unit 46th Annual Meeting;June 1215 2006; Boca Raton FL."},{"key":"e_1_2_5_10_2","unstructured":"MoncriefS CurtisS KrishnanS.Pharmacokinetics of NRP 104 (lisdexamfetamine dimesylate) following administration of a single intranasal intravenous or oral dose in rats. Poster presented at: Institute on Psychiatric Services 58th Annual Meeting;October 58 2006; New York."},{"key":"e_1_2_5_11_2","unstructured":"ErmerJC ShojaeiA BiedermanJ KrishnanS.Improved interpatient pharmacokinetic variability of lisdexamfetamine dimesylate compared with mixed amphetamine salts extended release in children aged 6 to 12 years with attention\u2010deficit\/hyperactivity disorder. Poster presented at: American Psychiatric Association 160th Annual Meeting;May 1924 2007; San Diego CA."},{"key":"e_1_2_5_12_2","article-title":"Lisdexamfetamine dimesylate and mixed amphetamine salts extended\u2010release in children with ADHD: a double\u2010blind, placebo\u2010controlled, crossover analog classroom study","author":"Biederman J","journal-title":"Biol Psychiatry"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.22.16.1405.33687"},{"key":"e_1_2_5_14_2","volume-title":"Vyvanse [package insert]","year":"2007"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F0091270007310381","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0091270007310381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T09:00:50Z","timestamp":1697101250000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/0091270007310381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1177\/0091270007310381"],"URL":"https:\/\/doi.org\/10.1177\/0091270007310381","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}