{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:15:32Z","timestamp":1790795732963,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":1679,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p>The effect of oral contraceptives (OCs) on melatonin metabolism was studied in 29 subjects genotyped for <jats:italic>CYP1A<\/jats:italic>2 SNP g.\u2010163C&gt;A polymorphism. Plasma melatonin and 6\u2010OH\u2010melatonin concentrations were measured after a 6\u2010mg dose of melatonin using a validated liquid chromatography\/mass spectrometry method. The mean melatonin AUC and C<jats:sub>max<\/jats:sub> values were 4\u2010 to 5\u2010fold higher in OC users than in non\u2010OC users (<jats:italic>P<\/jats:italic> &lt; .0001), whereas the weight\u2010adjusted clearance was significantly lower in OC users (<jats:italic>P<\/jats:italic> &lt; .0001). No significant difference in melatonin pharmacokinetics between the genotypes and no additional effect by the genotype on the OC\u2010induced increase in melatonin exposure were evident. Melatonin exposure had no significant effect on the subjects' state of alertness. In conclusion, a significant inhibitory effect of OCs on the CYP1A2\u2010catalyzed melatonin metabolism was seen; thereby, OC use can alter CYP1A2\u2010phenotyping results.<\/jats:p>","DOI":"10.1177\/0091270008318669","type":"journal-article","created":{"date-parts":[[2008,5,20]],"date-time":"2008-05-20T00:45:07Z","timestamp":1211244307000},"page":"986-994","source":"Crossref","is-referenced-by-count":36,"title":["The Effect of Oral Contraceptives on the Pharmacokinetics of Melatonin in Healthy Subjects With <i>CYP1A2<\/i> g.\u2010163C&gt;A Polymorphism"],"prefix":"10.1002","volume":"48","author":[{"given":"Johanna","family":"Hilli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Korhonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miia","family":"Turpeinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juho","family":"Hokkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sampo","family":"Mattila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Laine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"414","article-title":"Interindividual variations in human liver cytochrome P\u2010450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians","volume":"270","author":"Shimada T","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2173"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.64.3.659"},{"key":"e_1_2_5_5_2","unstructured":"Ingelman\u2010SundbergM DalyAK NebertDW eds.Home page of the Human Cytochrome P450 (CYP) Allele Nomenclature Committee. 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