{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:41:29Z","timestamp":1757454089185,"version":"3.37.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":1406,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p>Lipid\u2010lowering agents, 3\u2010hydroxy\u20103\u2010methylglutaryl\u2010coenzyme A reductase inhibitors (statins), are widely used to prevent coronary artery disease and often coadministered with other drugs, but there is a possibility that they induce pharmacological interactions with concomitant drugs. The authors aimed to investigate whether statins have any influence on cytochrome P450 (CYP) 3A4 enzyme activity. Eleven healthy volunteers were enrolled and evaluated for the effects of statins on the pharmacokinetics of midazolam in an open\u2010label, randomized, 3\u2010way crossover trial with simvastatin 10 mg, atorvastatin 10 mg, and pitavastatin 2 mg. The statins had no effects on the pharmacokinetics of midazolam and its metabolite, 1\u2032\u2010hydroxymidazolam. Furthermore, the area under the concentration\u2010time curve ratios for 1\u2032\u2010hydroxymidazolam\/midazolam from 0 to 10 hours showed no significant differences among 3 statins (simvastatin: 0.32 \u00b1 0.09, atorvastatin: 0.31 \u00b1 0.09, and pitavastatin: 0.31 \u00b1 0.12). 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