{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:45:24Z","timestamp":1792806324792,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":1406,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p>The purpose of this study is to analyze the effect of pregabalin (PGB) on pain alleviation, use of health care and non\u2014health care resources, and associated costs in patients with trigeminal neuralgia under usual clinical practice in primary care settings. Sixty\u2010five PGB\u2010na\u00efve patients receiving PGB as monotherapy (n = 36, 55%) or combined with other drugs (n = 29, 45%) fulfill criteria for inclusion in a secondary analysis from a 12\u2010week, multicenter, observational prospective study aimed to ascertain the cost of illness in subjects with neuropathic pain. Pain is evaluated using the Short Form McGill Pain Questionnaire. Use of health care and non\u2014health care resources and lost workdays equivalents (LWDEs) are also recorded. PGB significantly reduces pain scores, use of health care resources (ancillary tests and unscheduled medical visits), and number of LWDEs. Additional cost of PGB treatment (+\u20ac174 \u00b1 106) is broadly compensated for by a reduction in both health care costs (\u2212\u20ac621 \u00b1 1211, P &lt; .001) and indirect costs (\u2212\u20ac1210 \u00b1 1141, P &lt; .001). It is concluded that PGB as monotherapy or combined with other drugs is effective in pain management in patients with trigeminal neuralgia and reduces the cost of illness.<\/jats:p>","DOI":"10.1177\/0091270009333017","type":"journal-article","created":{"date-parts":[[2009,3,20]],"date-time":"2009-03-20T01:06:20Z","timestamp":1237511180000},"page":"582-590","source":"Crossref","is-referenced-by-count":20,"title":["Trigeminal Neuralgia Treated With Pregabalin in Family Medicine Settings: Its Effect on Pain Alleviation and Cost Reduction"],"prefix":"10.1002","volume":"49","author":[{"given":"Concepci\u00f3n","family":"P\u00e9rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda T.","family":"Salda\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Rejas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Classification of Chronic Pain","author":"Merskey H","year":"1994"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-002-0007-8"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00310-3"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.1.117"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200727110-00004"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2003.12.004"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2006.00079.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200201000-00004"},{"key":"e_1_2_5_10_2","unstructured":"Clinical Knowledge Summaries.Trigeminal neuralgia.http:cks.library.nhs.uktrigeminalneuralgiaviewwholeguidance. 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