{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:13:37Z","timestamp":1788783217869,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":1345,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>Propofol pharmacokinetics were examined in 17 adults with major burns during the hyperdynamic convalescent phase. Eighteen nonburned surgical patients served as controls. After a 2\u2010mg\/kg intravenous dose of propofol, blood samples were collected at multiple time points. Noncompartmental methods were used to calculate the pharmacokinetic parameters. The following indices were higher in burns than controls: propofol clearance (64 \u00b1 17 vs 29 \u00b1 4 mL\/kg\/min, <jats:italic>P<\/jats:italic> &lt; .001) and volume of distribution (8 \u00b1 3 vs 4 \u00b1 1 L\/kg, <jats:italic>P<\/jats:italic> &lt; .001). The area under the curve was smaller in burns (556 \u00b1 152 vs 1193 \u00b1 183 \u03bcg\/mL h, <jats:italic>P<\/jats:italic> &lt; .001). The higher clearance of propofol in burned patients may imply that these patients require higher doses or infusion rates of propofol to attain a target plasma concentration or pharmacodynamic effect.<\/jats:p>","DOI":"10.1177\/0091270009335767","type":"journal-article","created":{"date-parts":[[2009,6,24]],"date-time":"2009-06-24T21:27:25Z","timestamp":1245878845000},"page":"768-772","source":"Crossref","is-referenced-by-count":17,"title":["Propofol Clearance and Volume of Distribution Are Increased in Patients With Major Burns"],"prefix":"10.1002","volume":"49","author":[{"given":"Tae\u2010Hyung","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Greenblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A. 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