{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:00:44Z","timestamp":1770894044491,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":1345,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>The pharmacokinetics of oral contraceptive (OC) components, ethinyl estradiol (EE) and norethindrone (NET), were evaluated after coadministration with etoricoxib in 3 double\u2010blind, randomized, 2\u2010period crossover studies of healthy women. There were 16, 39, and 24 participants enrolled in studies 1 (part I, part II), and 2, respectively. Each participant received triphasic OC (EE 35 \u03bcg\/NET 0.5 mg \u00d7 7 days, 0.75 mg \u00d7 7 days, 1.0 mg \u00d7 7 days) throughout each 28\u2010day period. OC was coadministered with 21 days of etoricoxib daily followed by placebo for 7 days; the alternate period followed the reverse regimen (placebo to etoricoxib). Study 1 (part I) examined concurrent (morning) administration of OC\/etoricoxib 120 mg, study 1 (part II) examined staggered (morning\/night) administration of OC\/etoricoxib 120 mg, and study 2 examined concurrent (morning) administration of OC\/etoricoxib 60 mg. Coadministration of OC and etoricoxib 120 mg once daily was associated with a \u223c50% to 60% increase in EE concentrations, whereas etoricoxib 60 mg once daily was associated with a \u223c37% increase in EE concentrations. Coadministration of OC and etoricoxib was generally well tolerated. A clinically important change in NET AUC<jats:sub>0\u201324 h<\/jats:sub> was not observed. Adverse events included dyspepsia, diarrhea, headache, nausea, fatigue, loss of appetite, and taste disturbance.<\/jats:p>","DOI":"10.1177\/0091270009337131","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T01:29:37Z","timestamp":1242350977000},"page":"807-815","source":"Crossref","is-referenced-by-count":11,"title":["The Effect of Etoricoxib on the Pharmacokinetics of Oral Contraceptives in Healthy Participants"],"prefix":"10.1002","volume":"49","author":[{"given":"Jules","family":"Schwartz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William B.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Larson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tami","family":"Crumley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anish","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Gottesdiener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200746020-00003"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199936050-00001"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/00912709922007985"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00749.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2004.40.5.850488"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003251122"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00135-4"},{"key":"e_1_2_5_9_2","first-page":"813","article-title":"Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase\u20102 selective inhibitor","volume":"29","author":"Kassahun K","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.s1-3.1.62"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105173442007"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(03)00073-8"},{"key":"e_1_2_5_13_2","volume-title":"Lipitor [US package circular (atorvastatin calcium) tablets]","year":"2001"},{"key":"e_1_2_5_14_2","volume-title":"Sustiva [US package circular: (efavirenz) capsules]","year":"2001"},{"key":"e_1_2_5_15_2","volume-title":"Diflucan [US package circular: (fluconazole tablets) (fluconazole injection for intravenous infusion only) (fluconazole for oral suspension)]","year":"2001"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F0091270009337131","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0091270009337131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T22:47:58Z","timestamp":1697150878000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/0091270009337131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1177\/0091270009337131"],"URL":"https:\/\/doi.org\/10.1177\/0091270009337131","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}