{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T22:25:20Z","timestamp":1786227920842,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":1283,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p><jats:italic>Linezolid (Zyvox), belonging to oxazolidinone antibiotics, is commonly used for the treatment of patients infected with methicillin\u2010resistant<\/jats:italic> Staphylococcus aureus <jats:italic>and vancomycin\u2010resistant enterococci. Although linezolid has been approved worldwide, the Japanese pharmacokinetic (PK) profile has not been characterized in detail. The objective of this study is to develop a population PK model for linezolid that can be applied to a Japanese population. This population PK model was established based on the 1 Japanese phase III and 4 Caucasian phase II\/III studies. A total of 2539 linezolid plasma concentration measurements from 455 patients, aged 18 to 98 years and body weight 30 to 190.5 kg, were used for the analysis. The data were analyzed using nonlinear mixed effects modeling. Body weight (BW), age, ethnicity, and gender were investigated as covariates. The final model was validated by the bootstrap technique. The PK profiles of linezolid were described with a 1\u2010compartment PK model with first\u2010order absorption and first\u2010order elimination. In the final population PK model, BW and age were influential covariates on clearance, and the distribution volume was affected by BW. The present population PK model of linezolid described well the PK profiles in Japanese patients who have lower BW and are relatively older compared with those in the United States\/European Union<\/jats:italic>.<\/jats:p>","DOI":"10.1177\/0091270009337947","type":"journal-article","created":{"date-parts":[[2009,6,24]],"date-time":"2009-06-24T03:04:17Z","timestamp":1245812657000},"page":"1071-1078","source":"Crossref","is-referenced-by-count":92,"title":["Population Pharmacokinetic Analysis of Linezolid in Patients With Infectious Disease: Application to Lower Body Weight and Elderly Patients"],"prefix":"10.1002","volume":"49","author":[{"given":"Sadahiro","family":"Abe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Cirincione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaddeus H.","family":"Grasela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Suwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(02)00371-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(01)00334-0"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.8.2059"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/43.4.569"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.4.839"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.255"},{"key":"e_1_2_5_8_2","first-page":"1136","article-title":"Pharmacokinetics, metabolism, and excretion of linezolid following an oral dose of [14C] linezolid to healthy human subjects","volume":"29","author":"Slatter JG","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_5_9_2","first-page":"3","article-title":"In vitro metabolism of linezolid (PNU\u2010100766): lack of induction or inhibition of cytochrome P450 enzymes and studies on the mechanism of formation of the major human metabolite, PNU\u2010142586","volume":"39","author":"Wienkers LC","year":"1999","journal-title":"Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.19.15"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.21.61"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/383057"},{"key":"e_1_2_5_13_2","unstructured":"Annual report for the in\u2010hospital infection 8\u201312000[in Japanese].http:www.mhlw.go.jpshingi200210dls1010\u20103h1.pdf. 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