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The presence of a drug interaction was concluded if the 90% confidence intervals for the geometric least squares mean ratios of AUC<jats:sub>0\u2010t<\/jats:sub> (AUC<jats:sub>0\u201348<\/jats:sub> for levothyroxine) and C<jats:sub>max<\/jats:sub> fell outside the no\u2010effect limits of (80.0%, 125.0%). Concomitant administration of colesevelam had no effect on the AUC<jats:sub>0\u2010t<\/jats:sub> or C<jats:sub>max<\/jats:sub> of pioglitazone but significantly decreased the AUC<jats:sub>0\u2010t<\/jats:sub> and C<jats:sub>max<\/jats:sub> of glyburide, levothyroxine, and EE and the C<jats:sub>max<\/jats:sub> of repaglinide and NET. AUC<jats:sub>0\u2010t<\/jats:sub> and C<jats:sub>max<\/jats:sub> of glyburide and EE, but not repaglinide or NET, were significantly decreased when the drug was given 1 hour before colesevelam. When glyburide, EE, or levothyroxine was given 4 hours before colesevelam, no drug interaction was observed. Although colesevelam has a cleaner drug interaction profile than other bile acid sequestrants, it does interfere with absorption of some drugs. 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