{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:16:57Z","timestamp":1772749017767,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":827,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>This study investigates the potential benefits of antibiotics and N\u2010acetylcysteine (NAC), a mucolytic agent, in patients who are candidates for endoscopic retrograde cholangiopancreatography (ERCP) due to partial bile duct obstruction. In total, 102 patients who had choledocholithiasis and choledochal dilatations by abdominal ultrasonography were included in the study. The patients were divided into placebo and NAC therapy groups. Physiological saline (equal volume with NAC solution) and ciprofloxacin (2 \u00d7 200 mg\/d intravenously) were administered to the placebo group, and NAC (1800 mg\/d intravenously) and ciprofloxacin (2 \u00d7 200 mg\/d intravenously) were administered to the NAC group. In both groups, treatment protocols were administered for 7 days before ERCP. Total and direct bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), C\u2010reactive protein (CRP), alkaline phosphatase (ALP), gamma\u2010glutamyl transpeptidase (GGT), white blood cell (WBC) count, and neutrophil percent (NE%) levels were measured before the 7\u2010day treatment protocol. The same measurements were also evaluated before ERCP. In the NAC group, the levels of ALP, GGT, WBC, CRP, and NE% decreased significantly (P &lt; .001), whereas a significant decrease did not occur in the placebo group. The combined usage of NAC and ciprofloxacin can be an alternative therapeutic option until ERCP is performed in partial cholestatic patients.<\/jats:p>","DOI":"10.1177\/0091270010361257","type":"journal-article","created":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T02:17:19Z","timestamp":1271211439000},"page":"1414-1419","source":"Crossref","is-referenced-by-count":22,"title":["Potential Benefits of Combined N\u2010Acetylcysteine and Ciprofloxacin Therapy in Partial Biliary Obstruction"],"prefix":"10.1002","volume":"50","author":[{"given":"Burhan","family":"Ozdil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Kece","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arif","family":"Cosar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikmet","family":"Akkiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macit","family":"Sandikci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800790720"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3281532b78"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v8.i1.150"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20066"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5909"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0436SF"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060146"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.3.1800"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200525060-00005"},{"key":"e_1_2_5_11_2","first-page":"425","article-title":"Role of N\u2010acetylcysteine in the management of COPD","volume":"1","author":"Sadowska AM","year":"2006","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00069004"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.11.2658"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760210160"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106273242604"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(98)90506-6"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(89)90066-X"},{"key":"e_1_2_5_18_2","first-page":"45","article-title":"Toxicological, pharmacokinetic and metabolic studies on acetylcysteine","volume":"111","author":"Bonanomi L","year":"1980","journal-title":"Eur J Respir Dis"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02044114"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/pupt.1999.0219"},{"key":"e_1_2_5_21_2","first-page":"114","article-title":"Clinical applications of N\u2010acetylcysteine","volume":"3","author":"Kelly GS","year":"1998","journal-title":"Alt Med Rev"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240531040"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2000.00736.x"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F0091270010361257","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0091270010361257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0091270010361257","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0091270010361257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T13:54:22Z","timestamp":1698933262000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/0091270010361257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1177\/0091270010361257"],"URL":"https:\/\/doi.org\/10.1177\/0091270010361257","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}