{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:45:36Z","timestamp":1767980736454,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":279,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>This exploratory randomized, double\u2010blind, placebo\u2010controlled, 5\u2010treatment, 5\u2010period crossover study was conducted using a thermally induced hyperalgesia pain model in 51 healthy volunteers (33 evaluable) to characterize the relative potency of fentanyl buccal tablet (FBT) versus intravenous morphine. Relative potency was assessed using the sum of pain intensity differences over 60 minutes after the application of a 43\u00b0C, 46\u00b0C, and 49\u00b0C painful stimulus following thermally induced hyperalgesia. Relative potency was also assessed by pupil diameter and responses to subjective questionnaires. The relative potency of FBT was 46.2 times that of intravenous morphine (95% confidence interval [CI], 17.6\u2013575.3) based on the 49\u00b0C stimulus. The relative potency of FBT based on opiate\u2010induced miosis was 44.6 (95% CI, 29.7\u201377.0) at 60 minutes. These results are an initial relative potency assessment and should not be considered guidance for dose\u2010equivalent switching between agents in clinical practice.<\/jats:p>","DOI":"10.1177\/0091270011407496","type":"journal-article","created":{"date-parts":[[2011,6,7]],"date-time":"2011-06-07T02:29:27Z","timestamp":1307413767000},"page":"870-879","source":"Crossref","is-referenced-by-count":9,"title":["Assessment of the Relative Potency of Fentanyl Buccal Tablet to Intravenous Morphine in Healthy Volunteers Using a Thermally Induced Hyperalgesia Pain Model"],"prefix":"10.1002","volume":"52","author":[{"given":"David L.","family":"Saunders","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Messina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Darwish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Leary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis R.","family":"Cantilena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(01)00271-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(01)00294-9"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199809000-00018"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.2.385"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199811000-00005"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199806000-00022"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4020-5947-6","volume-title":"Opioids in Medicine: a Comprehensive Review on the Mode of Action and the Use of Analgesics in Different Pain States","author":"Freye E","year":"2008"},{"key":"e_1_2_6_9_2","first-page":"547","volume-title":"Goodman & Gilman's the Pharmacological Basis of Therapeutics","author":"Gutstein HB","year":"2006"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.2165\/00137696-200604010-00001"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.04.007"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X162818"},{"key":"e_1_2_6_13_2","first-page":"327","article-title":"Fentanyl buccal tablet for relief of breakthrough pain in opioid\u2010tolerant patients with cancer\u2010related chronic pain","volume":"5","author":"Slatkin NE","year":"2007","journal-title":"J Support Oncol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000210932.27945.4a"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24279"},{"key":"e_1_2_6_16_2","volume-title":"FENTORA [package insert]","year":"2011"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-3565(25)38451-X","article-title":"A dose\u2010response analysis of the subjective, psychomotor and physiological effects of intravenous morphine in healthy volunteers","volume":"268","author":"Zacny JP","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270006297749"},{"key":"e_1_2_6_19_2","volume-title":"Statistical Methods in Biological Assay","author":"Finney DJ","year":"1978"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200645080-00006"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200009000-00009"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1989.tb05399.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199909000-00038"},{"key":"e_1_2_6_24_2","first-page":"3","article-title":"Experimental cutaneous hyperalgesia in humans","volume":"11","author":"Petersen KL","year":"1997","journal-title":"IASP Newsletter"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270006294129"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(81)90099-3"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199710000-00019"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199610000-00009"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.06.001"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F0091270011407496","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0091270011407496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:33:17Z","timestamp":1741221197000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/0091270011407496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1177\/0091270011407496"],"URL":"https:\/\/doi.org\/10.1177\/0091270011407496","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}