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The study was conducted on 77 patients with newly diagnosed idiopathic pulmonary arterial hypertension at Fu Wai Hospital between September 2005 and September 2009. Patients were divided into 2 groups: the sildenafil group and the conventional group. Nine patients treated with sildenafil were re\u2010evaluated by right heart catheterization after 3 months. Our data demonstrated that the 6\u2010minute walk distance, World Health Organization functional class, mixed venous oxygen saturation, and hemodynamics significantly improved after 3 months of sildenafil therapy (P &lt; <jats:italic>.05). The baseline characteristics of the sildenafil group were similar to those of the conventional group. The 1\u2010, 2\u2010, and 3\u2010year survival rates in the sildenafil group were 88%, 72%, and 68% compared with 61%, 36%, and 27% in the conventional group (<\/jats:italic>P &lt; <jats:italic>.001)<\/jats:italic>. The absence of sildenafil therapy, lower body mass index, and lower mixed venous oxygen saturation were found to be independent predictors of mortality. In conclusion, sildenafil therapy was found to be associated with improved survival in patients with idiopathic pulmonary arterial hypertension.<\/jats:p>","DOI":"10.1177\/0091270011418656","type":"journal-article","created":{"date-parts":[[2011,9,29]],"date-time":"2011-09-29T01:34:34Z","timestamp":1317260074000},"page":"1357-1364","source":"Crossref","is-referenced-by-count":9,"title":["Impact of Sildenafil on Survival of Patients With Idiopathic Pulmonary Arterial 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