{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:21:43Z","timestamp":1773289303662,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":157,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>The aim of this study was to compare xanthine oxidase (XO) and N\u2010acetyltransferase\u20102 (NAT2) genotype and phenotype between Swedes (n = 113) and Koreans (n = 150), as well as to investigate the effect of sex, smoking, age, and oral contraceptive (OC) use on enzyme activities, using caffeine as a probe. XO and NAT2 activities were estimated by 1U\/(1U+1X) and AFMU\/(AFMU+1X+1U) urinary ratios, respectively. Participants were genotyped for 191G&gt;A, 341T&gt;C, 590G&gt;A, and 857G&gt;A NAT2 polymorphisms. There was no significant difference in XO activity between Swedes and Koreans. In Swedes, higher XO activity was observed in women (P &lt; .003). There were significant differences in NAT2 genotype and phenotype between Swedes and Koreans. Koreans display significantly higher frequency of NAT2 fast acetylator genotype (89%), whereas the slow acetylator genotype is predominant (62%) in Swedes (P &lt; .0001). Significantly higher NAT2 activity was observed in Koreans compared to Swedes (P &lt; .0001). Having the same NAT2 fast acetylator genotype, Koreans display higher enzyme activity than Swedes (P &lt; .004). OC use significantly increased NAT2 activity in Swedish women. In conclusion, Koreans display higher NAT2 activity than Swedes regardless of NAT2 genotype. Ethnicity, OC use, and genotype determine NAT2 activity, whereas sex is the only determinant of XO activity.<\/jats:p>","DOI":"10.1177\/0091270011420261","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T07:01:56Z","timestamp":1321945316000},"page":"1527-1534","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of <i>N<\/i>\u2010Acetyltransferase\u20102 Enzyme Genotype\u2010Phenotype and Xanthine Oxidase Enzyme Activity Between Swedes and Koreans"],"prefix":"10.1002","volume":"52","author":[{"given":"Natasa","family":"Djordjevic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"Carrillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung\u2010Keun","family":"Roh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhisa","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif","family":"Bertilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Aklillu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1991.205"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(00)00203-9"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.1.6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-008-0597-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3282f55e2e"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00956-5"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-003-0653-8"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.736"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.203"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1517\/14622416.3.3.349"},{"key":"e_1_2_5_12_2","first-page":"683","article-title":"Distribution and concordance of N\u2010acetyltransferase genotype and phenotype in an American population","volume":"8","author":"Gross M","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.2174\/156802606778108979"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/03602530500251204"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.126173"},{"key":"e_1_2_5_16_2","first-page":"225","article-title":"Arylamine N\u2010acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking","volume":"6","author":"Okkels H","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199810000-00013"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.07.024"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(89)90036-3"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0288-2"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200008000-00008"},{"key":"e_1_2_5_22_2","first-page":"125","article-title":"Arylamine N\u2010acetyltransferase 2 polymorphism in the ethnic populations of South India","volume":"11","author":"Anitha A","year":"2003","journal-title":"Int J Mol Med"},{"key":"e_1_2_5_23_2","article-title":"N\u2010acetyltransferase\u20102 (NAT2) gene polymorphisms and enzyme activity in Serbs: unprecedented high prevalence of rapid acetylators in a white population","author":"Djordjevic N","year":"2010","journal-title":"J Clin Pharmacol"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1991.176"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199606000-00006"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-010-0785-6"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.104617"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(95)00093-Q"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(95)02014-4"},{"key":"e_1_2_5_30_2","first-page":"581","article-title":"Arylamine N\u2010acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity","volume":"57","author":"Cascorbi I","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_31_2","first-page":"449","article-title":"Predictors of N\u2010acetyltransferase activity: should caffeine phenotyping and NAT2 genotyping be used interchangeably in epidemiological studies?","volume":"5","author":"Marchand L","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1517\/14622416.3.1.19"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-003-0606-2"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2009.01065.x"},{"key":"e_1_2_5_35_2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/clinchem\/48.5.775","article-title":"Complete sequencing of a genetic polymorphism in NAT2 in the Korean population","volume":"48","author":"Lee S","year":"2002","journal-title":"Clin Chem"},{"key":"e_1_2_5_36_2","first-page":"506","article-title":"Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis","author":"Hein DW","year":"2002","journal-title":"Mutat Res"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270006288955"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2009.4"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F0091270011420261","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0091270011420261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:03:30Z","timestamp":1697457810000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/0091270011420261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1177\/0091270011420261"],"URL":"https:\/\/doi.org\/10.1177\/0091270011420261","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}