{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:08:25Z","timestamp":1781885305856,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":126,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Two open\u2010label, randomized, multiple\u2010dose clinical studies evaluated the potential for pharmacokinetic interaction between the antiepileptic drugs lacosamide and valproic acid. The influence of lacosamide on valproic acid pharmacokinetics (trial A) and valproic acid on lacosamide pharmacokinetics (trial B) was investigated in 32 healthy male volunteers, 16 in each trial. Volunteers in trial A received valproic acid (300 mg bid) with randomization to either early or late addition of lacosamide (200 mg bid). Those in trial B received lacosamide (200 mg bid) with randomization to either early or late addition of valproic acid (300 mg bid). Area under the concentration\u2010time curve during a 12\u2010hour dosing interval at steady state (AUC<jats:sub>TSS<\/jats:sub>) and maximum steady\u2010state plasma drug concentration (C<jats:sub>max, ss<\/jats:sub>) were measured for each drug alone and together and tested for equivalence. The point estimates (90% confidence intervals) for <jats:sub>AUCt, ss<\/jats:sub> and C<jats:sub>max, ss<\/jats:sub> were 104% (99%\u2013109%) and 101% (97%\u2013107%), respectively, for valproic acid and 100% (98%\u2013103%) and 101% (96%\u2013107%), respectively, for lacosamide, which were within the generally accepted equivalence range of 80% to 125%. No changes in the rate or extent of absorption, terminal half\u2010life, or time to maximum concentration were observed. These results suggest that lacosamide and valproic acid have no relevant pharmacokinetic drug\u2010drug interaction.<\/jats:p>","DOI":"10.1177\/0091270011426875","type":"journal-article","created":{"date-parts":[[2011,12,10]],"date-time":"2011-12-10T01:30:22Z","timestamp":1323480622000},"page":"1739-1748","source":"Crossref","is-referenced-by-count":52,"title":["No Pharmacokinetic Interaction Between Lacosamide and Valproic Acid in Healthy Volunteers"],"prefix":"10.1002","volume":"52","author":[{"given":"Willi","family":"Cawello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Bonn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.13001.x"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02238.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666140-00004"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2008.44.1.1178468"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2006.10.002"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2007.00001.x"},{"key":"e_1_2_9_8_2","volume-title":"UCB Pharma S.A. Vimpat [summary of product characteristics]","year":"2008"},{"issue":"7","key":"e_1_2_9_9_2","first-page":"307","article-title":"Food does not affect the pharmacokinetics of SPM 927 [abstract]","volume":"45","author":"Cawello W","year":"2004","journal-title":"Epilepsia"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(02)00106-7"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.9.1.33"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.00326.x"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl096"},{"key":"e_1_2_9_14_2","volume-title":"Depakene (valproic acid) capsules and oral solution [US prescribing information]","author":"Abbott Laboratories","year":"2009"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009347675"},{"issue":"9","key":"e_1_2_9_16_2","first-page":"97","article-title":"Rudd GD. SPM 927 does not interact with valproic acid and carbamazepine [abstract]","volume":"44","author":"Horstmann R","year":"2003","journal-title":"Epilepsia"},{"key":"e_1_2_9_17_2","volume-title":"Note for Guidance on the Investigation of Bioavailability and Bioequivalence","author":"European Agency for the Evaluation of Medicinal Products","year":"2001"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01561.x"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198005010-00002"},{"issue":"7","key":"e_1_2_9_20_2","first-page":"188","article-title":"Rudd GD. Basic clinical pharmacologic investigations of the new antiepileptic drug SPM 927 [abstract]","volume":"43","author":"Horstmann R","year":"2002","journal-title":"Epilepsia"},{"key":"e_1_2_9_21_2","volume-title":"A.D.A.M. Medical Encyclopedia","author":"A.D.A.M., Inc.","year":"2005"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01188.x"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01951.x"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02496.x"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F0091270011426875","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0091270011426875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T21:22:09Z","timestamp":1697491329000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/0091270011426875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1177\/0091270011426875"],"URL":"https:\/\/doi.org\/10.1177\/0091270011426875","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}