{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:14:21Z","timestamp":1757780061611,"version":"3.40.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T00:00:00Z","timestamp":1371168000000},"content-version":"vor","delay-in-days":164,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>In this study, the authors compared the effects of amlodipine (AML) on the bioavailability of cephalexin (LEX) and cefuroxime axetil (CXM). Twenty\u2010four healthy men were randomized to 4 treatments according to a crossover design with a 14\u2010day washout. After an overnight fast, they were administered orally LEX 500 mg alone, LEX 500 mg 2 hours after oral administration of AML 5 mg, CXM 500 mg alone, and CXM 500 mg 2 hours after oral administration of AML 5 mg. All participants completed the whole study without side effects being observed. Pharmacokinetic data were analyzed by noncompartmental modeling with WinNonlin software. The geometric mean (GM) ratios were 1.38 (90% confidence interval [CI], 1.32\u20101.45) for the area under the concentration\u2010time curve (AUC) for LEX and 1.27 (1.18\u20101.36) for the maximum concentration of drug in serum (C<jats:sub>max<\/jats:sub>) for LEX followed by AML versus alone. In contrast, no significant differences were found in the pharmacokinetic parameters of CXM between treatments (<jats:italic>P<\/jats:italic>&lt; .05). They authors conclude that AML possesses an enhancement effect in \u03b2\u2010lactam antibiotic bioavailability (in this case, LEX), and this interaction may be specific to the peptidomimetic \u03b2\u2010lactam antibiotics.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0091270011435327","type":"journal-article","created":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T06:07:34Z","timestamp":1327471654000},"page":"82-86","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Amlodipine on the Oral Bioavailability of Cephalexin and Cefuroxime Axetil in Healthy Volunteers"],"prefix":"10.1002","volume":"53","author":[{"given":"Yi","family":"Ding","sequence":"first","affiliation":[{"name":"Xijing Hospital of the Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WenXing","family":"Liu","sequence":"additional","affiliation":[{"name":"Xijing Hospital of the Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yan Jia","sequence":"additional","affiliation":[{"name":"Xijing Hospital of the Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChengTao","family":"Lu","sequence":"additional","affiliation":[{"name":"Xijing Hospital of the Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[{"name":"Xijing Hospital of the Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Xijing Hospital of the Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YanRong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Xijing Hospital of the Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"Xijing Hospital of the Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Song","sequence":"additional","affiliation":[{"name":"Xijing Hospital of the Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LiKun","family":"Ding","sequence":"additional","affiliation":[{"name":"Xijing Hospital of the Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AiDong","family":"Wen","sequence":"additional","affiliation":[{"name":"Xijing Hospital of the Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.5.0002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(87)90369-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.5.1375-1380.2002"},{"issue":"312","key":"e_1_2_8_5_1","article-title":"Nifedipine enhances amoxicillin absorption kinetics and bioavailability in humans","volume":"255","author":"Westphal JF","year":"1990","journal-title":"J Pharmacol Exp Ther"},{"issue":"1267","key":"e_1_2_8_6_1","article-title":"et al. 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