{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:45:54Z","timestamp":1792511154894,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T00:00:00Z","timestamp":1371168000000},"content-version":"vor","delay-in-days":164,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>To investigate the correlation between carbapenem consumption and rates of antimicrobial resistance in <jats:italic>Acinetobacter baumannii<\/jats:italic>, carbapenem consumption was expressed as defined daily dose based on the World Health Organization (WHO) anatomical therapeutic chemical classification index. Clinical isolates from 2001\u20102009 were collected and analyzed using WHONET 5.4 software. Results show that the consumption of imipenem\/cilastatin, meropenem, and total carbapenem is significantly correlated with imipenem resistance in <jats:italic>A baumannii<\/jats:italic> (<jats:italic>r<\/jats:italic> = 0.818, <jats:italic>P<\/jats:italic> = .007; <jats:italic>r<\/jats:italic> = 0.817, <jats:italic>P<\/jats:italic> = .007; <jats:italic>r<\/jats:italic> = 0.827, <jats:italic>P<\/jats:italic> = .006). Furthermore, total carbapenem consumption is significantly correlated with meropenem resistance in <jats:italic>A baumannii<\/jats:italic> (<jats:italic>r<\/jats:italic> = 0.900, <jats:italic>P<\/jats:italic> = .037). In addition, consumption of imipenem\/cilastatin, meropenem, and total carbapenem is associated with <jats:italic>A baumannii<\/jats:italic> resistance to piperacillin\u2010tazobactam, ceftazidime, cefepime, amikacin, and levofloxacin. These drugs are mainly \u03b2\u2010lactams, aminoglycosides, and fluoroquinolones. The imipenem and meropenem resistance rates are significantly correlated with resistance rates to numerous antimicrobial drugs (eg, \u03b2\u2010lactams, aminoglycosides, and fluoroquinolones) in <jats:italic>A baumannii<\/jats:italic>. Therefore, increased consumption of carbapenem may contribute to the development of resistance in <jats:italic>A baumannii<\/jats:italic> to imipenem, meropenem, and other antimicrobial drugs. Cross\u2010resistance possibly occurs among imipenem\/cilastatin and meropenem, as well as with \u03b2\u2010lactams, aminoglycosides, and fluoroquinolones.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0091270011435988","type":"journal-article","created":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T07:14:23Z","timestamp":1328253263000},"page":"96-102","source":"Crossref","is-referenced-by-count":28,"title":["Correlation Between Carbapenem Consumption and Antimicrobial Resistance Rates of <i>Acinetobacter baumannii<\/i> in a University\u2010Affiliated Hospital in China"],"prefix":"10.1002","volume":"53","author":[{"given":"Jia","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Pharmacy the First Affiliated Hospital of Nanjing Medical University  Nanjing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[{"name":"Respiratory Department the First Affiliated Hospital of Nanjing Medical University  Nanjing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory the First Affiliated Hospital of Nanjing Medical University  Nanjing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010 ning","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory the First Affiliated Hospital of Nanjing Medical University  Nanjing, P.R. 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