{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T00:04:45Z","timestamp":1700352285309},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":4418,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>The effect and metabolism of theophylline administration after cardiac surgery has never been reported. Two series of 2\u2010hour intravenous aminophylline administrations (3 mg\/kg\/h) were conducted in 10 adult patients on the operative day (acute phase) and on the 4th or 5th postoperative day (recovery phase). Both blood and urine samples were collected for 24 hours after dosing. Heart rate increased in both phases, but the cardiac index increased with the decrease of diastolic blood pressure only in the acute phase (p &lt; 0.05). Plasma concentration levels of theophylline tended to be slightly higher in the acute phase, and renal clearance increased in the recovery phase (p &lt; 0.05). The urinary ratio of 3\u2010methylxanthine to theophylline was significantly higher in the acute phase (p &lt; 0.05). This suggests that cytochrome P4501A2 is partially activated rather than depressed and that N\u2010demethylation is promoted more than hydroxylation immediately after surgery.<\/jats:p>","DOI":"10.1177\/00912700122009962","type":"journal-article","created":{"date-parts":[[2003,7,19]],"date-time":"2003-07-19T09:38:13Z","timestamp":1058607493000},"page":"157-162","source":"Crossref","is-referenced-by-count":2,"title":["Theophylline Metabolism after Cardiac Surgery"],"prefix":"10.1002","volume":"41","author":[{"given":"Kazunobu","family":"Hirooka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Mineshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1977213310"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102211"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/106002809402800319"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07030579"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199528050-00005"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199528040-00003"},{"key":"e_1_2_1_8_2","first-page":"408","article-title":"Apparent theophylline half\u2010life fluctuations during treatment of acute left ventricular failure","volume":"34","author":"Jenne JW","year":"1977","journal-title":"Am J Hosp Pham"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)63701-4"},{"key":"e_1_2_1_10_2","first-page":"210","volume-title":"Postoperative Care","author":"Kirklin JW","year":"1993"},{"key":"e_1_2_1_11_2","first-page":"827","article-title":"Theophylline N\u2010demethylations as probes for P4501A1 and P4501A2","volume":"22","author":"Sarkar MA","year":"1994","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198409040-00002"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1983.tb04531.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/20.4.155"},{"key":"e_1_2_1_15_2","first-page":"94","volume-title":"Non\u2010Compartmental Analysis","author":"Gabrielsson J","year":"1994"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.73.5.616"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-197803040-00002"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1983.tb01475.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)00120-O"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199901000-00011"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1987.tb03172.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90282-N"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F00912700122009962","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/00912700122009962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T08:41:45Z","timestamp":1700296905000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/00912700122009962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["10.1177\/00912700122009962"],"URL":"https:\/\/doi.org\/10.1177\/00912700122009962","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}