{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:46:21Z","timestamp":1792320381100,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":4329,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p>Linezolid is a novel oxazolidinone antibiotic with mild reversible monoamine oxidase inhibitor (MAOI) activity. The potential for interaction with over\u2010the\u2010counter (OTC) medications requires quantification. The authors present data evaluating the pharmacokinetic and pharmacodynamic responses to coadministration of oral linezolid with sympathomimetics (pseudoephedrine and phenylpropanolamine) and a serotonin reuptake inhibitor (dextromethorphan). Following coadministration with linezolid, minimal but statistically significant increases were observed in pseudoephedrine and phenylpropanolamine plasma concentrations; a minimal but statistically significant decrease was observed in dextrorphan (the primary metabolite of dextromethorphan) plasma concentrations. Increased blood pressure (BP) was observed following the coadministration of linezolid with either pseudoephedrine or phenylpropanolamine; no significant effects were observed with dextromethorphan. None of these coadministered drugs had a significant effect on linezolid pharmacokinetics. Minimal numbers of adverse events were reported. Potentiation of sympathomimetic activity by linezolid was judged not to be clinically significant, but patients sensitive to the effects of increased BP due to predisposing factors should be treated cautiously. No restrictions are indicated for the coadministration of dextromethorphan and linezolid.<\/jats:p>","DOI":"10.1177\/00912700122010302","type":"journal-article","created":{"date-parts":[[2003,7,19]],"date-time":"2003-07-19T09:38:13Z","timestamp":1058607493000},"page":"563-572","source":"Crossref","is-referenced-by-count":72,"title":["Linezolid: Pharmacokinetic and Pharmacodynamic Evaluation of Coadministration with Pseudoephedrine HCl, Phenylpropanolamine HCl, and Dextromethorphan HBr"],"prefix":"10.1002","volume":"41","author":[{"given":"Pamela E.","family":"Hendershot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Antal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"Welshman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald H.","family":"Batts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy K.","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"MartinJP HerbergJT SlatterJG DupuisMJ:Although a novel microtiter\u2010plate assay demonstrates that linezolid (PNU\u2010100766) is a weak competitive (reversible) inhibitor of human monoamine oxidase (MAO A) no clinical evidence of MAO A inhibition in clinical trials has been observed. Paper presented at the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy San Diego CA September 1998."},{"key":"e_1_2_1_3_2","unstructured":"PawseySD Daley\u2010YatesPT WajszczukCP StalkerDJ:U\u2010100766 Safety toleration and pharmacokinetics after oral and intravenous administration [abstract F151]. Paper presented at the European Congress of Antimicrobial Chemotherapy Glasgow Scotland May 1996."},{"key":"e_1_2_1_4_2","unstructured":"FeenstraKL SlatterJG StalkerDJ WelshmanIR HauerMJ CathcartKS et al:Metabolism and excretion of the oxazolidinone antibiotic linezolid (PNU\u2010100766) following oral administration of [14C]PNU\u2010100766 to healthy volunteers. Paper presented at the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy San Diego CA September 1998."},{"key":"e_1_2_1_5_2","unstructured":"StalkerDJ WajszczukCP BattsDH:Linezolid safety tolerance and pharmacokinetics following oral dosing twice daily for 14.5 days. Paper presented at the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy Toronto September 1997."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/00912709922011962"},{"key":"e_1_2_1_7_2","unstructured":"StalkerDJ WajszczukCP BattsDH:Linezolid safety tolerance and pharmacokinetics after intravenous dosing twice daily for 7.5 days. Paper presented at the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy Toronto September 1997."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122010294"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327197016001031"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.6.705"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1993.12"},{"key":"e_1_2_1_12_2","first-page":"85","article-title":"Possible lethal reaction between nardil and dextromethorphan [letter]","volume":"103","author":"Rivers N","year":"1970","journal-title":"Canad Med Assoc Jour"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03010890"},{"key":"e_1_2_1_14_2","first-page":"S100","article-title":"Pharmacokinetics of dextromethorphan and guaifenesin following administration of Benylin DME expectorant in healthy volunteers","volume":"4","author":"Selen A","year":"1987","journal-title":"Pharm Res"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199508000-00005"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"S\u2010374","DOI":"10.1023\/A:1012142204132","article-title":"Determination of linezolid, PNU\u2010100766, in human plasma and urine using high\u2010performance liquid chromatography with ultraviolet detection","volume":"14","author":"Johnson RA","year":"1997","journal-title":"Pharm Research"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)81077-4"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(85)80074-8"},{"key":"e_1_2_1_19_2","volume-title":"Clinical Pharmacokinetics Analysis Program, version 1.0 user manual","author":"Trilogy Consulting Corporation","year":"1996"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1201\/b14095"},{"key":"e_1_2_1_21_2","volume-title":"SAS\/STAT User's Guide","year":"1990"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.77"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(96)90056-9"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(95)00574-9"},{"key":"e_1_2_1_25_2","unstructured":"WienkersLC WynaldaMA FeenstraKL GaoP SlatterJG:In vitro metabolism of cytochrome P450 enzymes and studies on the mechanism of formation of the major human metabolite PNU\u2010142586. Paper presented at the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy San Francisco September 1999."},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199300730-00008"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199107000-00012"},{"issue":"6","key":"e_1_2_1_28_2","first-page":"116S","article-title":"Pharmacokinetics of oral decongestants","volume":"13","author":"Kanfer I","year":"1993","journal-title":"Pharmacotherapy"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F00912700122010302","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/00912700122010302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T22:17:27Z","timestamp":1696630647000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/00912700122010302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["10.1177\/00912700122010302"],"URL":"https:\/\/doi.org\/10.1177\/00912700122010302","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}