{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:31:51Z","timestamp":1770219111832,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":5971,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[1996,11]]},"abstract":"<jats:p>In a recently reported case, administration of omeprazole, a \u201cproton pump\u201d inhibitor, was temporally associated with the clinical relapse of pemphigus in a 44\u2010year\u2010old woman whose condition had been stabilized with a fixed dose of prednisone, suggesting the possibility of a drug interaction. This placebo\u2010controlled, randomized, double\u2010blind, three\u2010period crossover study was conducted to evaluate and compare the pharmacokinetics of prednisolone after a single dose of prednisone given during multi\u2010dose administration of lansoprazole or omeprazole. Lansoprazole (30 mg), omeprazole (40 mg), or placebo was administered once daily under fasted conditions for 7 days to healthy male volunteers. On the seventh day, a single dose of prednisone (40 mg) was administered concomitantly with the study medication, and plasma prednisolone concentrations were measured by high\u2010performance liquid chromatography for 24 hours thereafter. Two weeks separated the first doses of each study period. Eighteen volunteers entered the study; pharmacokinetic data were evaluable for 15 participants. Safety data were evaluable for 16 participants in the lansoprazole\/prednisone group; 17 in the omeprazole\/prednisone group; and 17 in the placebo\/prednisone group. The pharmacokinetic parameters for prednisolone, including the maximum observed plasma concentration (C<jats:sub>max<\/jats:sub>), time to maximum plasma concentration (t<jats:sub>max<\/jats:sub>), terminal\u2010phase half\u2010life (t<jats:sub>1\/2<\/jats:sub>), and area under the concentration\u2014time curve, were comparable for the three regimens. Adverse events (AEs) rated as possibly or probably drug related were reported by 50%, 24%, and 47% for subjects in the lansoprazole, omeprazole, and placebo treatment groups, respectively. Headache was the most common drug\u2010related AE. No serious AEs were reported, and no subject withdrew from the study because of an AE. Concomitant administration of lansoprazole or omeprazole does not affect the absorption, biotransformation, or disposition of a single dose of prednisone. All three treatment regimens were well tolerated.<\/jats:p>","DOI":"10.1177\/009127009603601110","type":"journal-article","created":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T00:52:18Z","timestamp":1182473538000},"page":"1064-1071","source":"Crossref","is-referenced-by-count":9,"title":["Lack of Pharmacokinetic Interaction after Administration of Lansoprazole or Omeprazole with Prednisone"],"prefix":"10.1002","volume":"36","author":[{"given":"John H.","family":"Cavanaugh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Karol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1989.tb00205.x"},{"issue":"1","key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-2036.1993.tb00589.x","article-title":"An open trial of long\u2010term therapy with lansoprazole in patients with peptic ulceration resistant to extended high\u2010dose ranitidine treatment","volume":"7","author":"Brunner G","year":"1993","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_2_1_4_2","first-page":"1191","article-title":"Double\u2010blind comparison of lansoprazole, ranitidine, and placebo in the treatment of acute duodenal ulcer","volume":"89","author":"Lanza F","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_1_5_2","first-page":"1212","article-title":"Treatment of reflux esophagitis resistant to H2\u2010receptor antagonists with lansoprazole, a new H@\/K@\u2010ATPase inhibitor: a controlled, double\u2010blind study","volume":"88","author":"Feldman M","year":"1993","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1365-2036.1993.tb00588.x","article-title":"Prospective study of the long\u2010term efficacy and safety of lansoprazole in patients with the Zollinger\u2010Ellison syndrome","volume":"7","author":"Jensen RT","year":"1993","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.3.490"},{"key":"e_1_2_1_8_2","first-page":"410","article-title":"Oxidative metabolism of lansoprazole by human liver cytochromes P450","volume":"47","author":"Pichard L","year":"1995","journal-title":"Mol Pharmacol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199121030-00004"},{"key":"e_1_2_1_10_2","first-page":"45","article-title":"Pemphigoide Bulleuse Secondairement Corticoresistante: Role inhibiteur de l'omeprazole sur le metabolisme des corticoides","volume":"118","author":"Chosidow O","year":"1991","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_1_11_2","first-page":"682","article-title":"Possible interaction prednisone\u2010omeprazole dans la pemphigo\u00efe bulleuse","volume":"14","author":"Joly P","year":"1990","journal-title":"Gastroenterologie Clinique et Biologique"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/03610929008830386"},{"key":"e_1_2_1_13_2","volume-title":"\u201cCOSTART\u201d Coding Symbols for Thesaurus of Adverse Reaction Terms.","author":"United States Department of Health and Human Services","year":"1989"},{"key":"e_1_2_1_14_2","volume-title":"SAS\/STAT User's Guide: Statistics.","author":"SAS Institute","year":"1990"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02657057"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03257393"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1984.tb02452.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90638-9"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1987.tb03209.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-198903000-00010"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00266355"},{"key":"e_1_2_1_22_2","first-page":"1097","article-title":"Omeprazole\u2010cyclosporin interaction","volume":"86","author":"Schouler LF","year":"1991","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.172"},{"key":"e_1_2_1_24_2","first-page":"A103","article-title":"Lack of effect of concomitant multi\u2010dose lansoprazole on single\u2010dose phenytoin pharmacokinetics in subjects (abstract)","volume":"106","author":"Karol MD","year":"1994","journal-title":"Gastroenterology"},{"key":"e_1_2_1_25_2","first-page":"A40","article-title":"Effect of lansoprazole on antipyrine and ICG pharmacokinetics (abstract)","volume":"100","author":"Cavanaugh JH","year":"1991","journal-title":"Gastroenterology"},{"key":"e_1_2_1_26_2","first-page":"S295","article-title":"Lack of effect of lansoprazole on warfarin pharmacokinetics and anticoagulation effect in healthy subjects (abstract)","volume":"8","author":"Braeckman RA","year":"1991","journal-title":"Pharm Res"},{"key":"e_1_2_1_27_2","first-page":"A40","article-title":"Lack of effect of lansoprazole on steady state warfarin metabolism (abstract)","volume":"100","author":"Cavanaugh JH","year":"1991","journal-title":"Gastroenterology"},{"key":"e_1_2_1_28_2","first-page":"A4","article-title":"Lack of effect of concomitant lansoprazole on single\u2010dose propranolol pharmacokinetics and pharmacodynamics (abstract)","volume":"106","author":"Cavanaugh JH","year":"1994","journal-title":"Gastroenterology"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1994.tb04370.x"},{"key":"e_1_2_1_30_2","first-page":"A75","article-title":"Lack of effect of concomitant lansoprazole on steady\u2010state theophylline pharmacokinetics (abstract)","volume":"100","author":"Granneman G","year":"1991","journal-title":"Gastroenterology"},{"key":"e_1_2_1_31_2","first-page":"805","article-title":"Identification of the human P450 enzymes involved in lansoprazole metabolism","volume":"277","author":"Pearce RE","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_32_2","first-page":"410","article-title":"Oxidative Metabolism of Lansoprazole by Human Liver Cytochromes P450","volume":"47","author":"Pichard L","year":"1995","journal-title":"Mol Pharmacol"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.3109\/03602539508998329"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199019020-00003"},{"key":"e_1_2_1_35_2","first-page":"460","volume-title":"The Esophageal Mucosa: 300 Questions, 300 Answers.","author":"Rodrigues AD","year":"1994"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F009127009603601110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/009127009603601110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T16:28:41Z","timestamp":1698337721000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/009127009603601110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1996,11]]}},"alternative-id":["10.1177\/009127009603601110"],"URL":"https:\/\/doi.org\/10.1177\/009127009603601110","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,11]]}}}