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In this manner, NF\u2010\u03baB contributes to immunologically mediated diseases such as allograft rejection, rheumatoid arthritis, and bronchial asthma. The prototypic inducible form of NF\u2010\u03baB is a heterodimer composed of NF\u2010kB1 and RelA, which both belong to the NF\u2010\u03baB\/Rel family of proteins. Inactive NF\u2010\u03baB is present in the cytoplasm complexed with an inhibitory protein, I\u03baB. NF\u2010\u03baB is activated by a number of incoming signals from the cell surface. Released from I\u03baB inhibition, NF\u2010\u03baB translocates into the nucleus and binds to the \u03baB motif of the target gene. The NF\u2010\u03baB activation process can be inhibited by pharmacologic agents at each activation step. Glucocorticoids inhibit NF\u2010\u03baB by directly associating with NF\u2010\u03baB or by upregulating I\u03baB expression. Cyclosporin and tacrolimus prevent NF\u2010\u03baB activation by inhibiting the action of calcineurin, a phosphatase that indirectly induces I\u03baB degradation. Deoxyspergualin inhibits NF\u2010\u03baB by blocking its nuclear translocation. Aspirin and salicylates inhibit upstream events inducing I\u03baB phosphorylation. Tepoxalin and antioxidants inhibit NF\u2010\u03baB activation by influencing the redox state of the cell. 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