{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T06:13:12Z","timestamp":1698559992072},"reference-count":5,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":5241,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:p>This study was conducted to compare the value of an older formulation of potassium\u2010magnesium citrate (K<jats:sub>4<\/jats:sub>MgCit<jats:sub>2<\/jats:sub>) with newer formulations (K<jats:sub>3<\/jats:sub>MgHCit<jats:sub>2<\/jats:sub> and K<jats:sub>5<\/jats:sub>MgCit<jats:sub>2<\/jats:sub>Cl) with respect to the correction of thiazide\u2010induced hypokalemia and magnesium loss, alkalinizing effect, and citraturic action. Sixty\u2010two healthy volunteers first took hydrochlorothiazide 50 mg\/day. After 3 weeks of thiazide treatment (or earlier if hypokalemia developed), they were randomized to take one of three drugs for 3 weeks while continuing thiazide: K<jats:sub>4<\/jats:sub>MgCit<jats:sub>2<\/jats:sub> (49 mEq K, 25 mEq Mg, and 74 mEq citrate\/day), K<jats:sub>3<\/jats:sub>MgHCit<jats:sub>2<\/jats:sub> (49 mEq K, 33 mEq Mg, and 98 mEq citrate\/day), and K<jats:sub>5<\/jats:sub>MgCit<jats:sub>2<\/jats:sub>Cl (49 mEq K, 20 mEq Mg, 10 mEq Cl and 59 mEq citrate\/day). Outcome measures were changes in serum potassium and magnesium, and urinary potassium, magnesium, pH, and citrate. The three drugs were equally effective in correcting thiazide\u2010induced hypokalemia. K<jats:sub>3<\/jats:sub>MgHCit<jats:sub>2<\/jats:sub> and K<jats:sub>4<\/jats:sub>MgCit<jats:sub>2<\/jats:sub> produced a small but significant increase in serum magnesium concentration, whereas K<jats:sub>5<\/jats:sub>MgCit<jats:sub>2<\/jats:sub>Cl did not. Although all three supplements significantly increased urinary pH and citrate, these effects were more marked with K<jats:sub>3<\/jats:sub>MgHCit<jats:sub>2<\/jats:sub> and K<jats:sub>4<\/jats:sub>MgCit<jats:sub>2<\/jats:sub> than with K<jats:sub>5<\/jats:sub>MgCit<jats:sub>2<\/jats:sub>Cl. All three supplements were generally well tolerated, with the lowest side effect profile obtained with K<jats:sub>4<\/jats:sub>MgCit<jats:sub>2<\/jats:sub>. The new formulation of K<jats:sub>3<\/jats:sub>MgHCit<jats:sub>2<\/jats:sub> exerts similar correction of thiazide\u2010induced hypokalemia and magnesium loss, and enhancement of urinary pH and citrate, compared with the older K<jats:sub>4<\/jats:sub>MgCit<jats:sub>2<\/jats:sub>. However, it is less well tolerated. The new formulation of K<jats:sub>5<\/jats:sub>MgCit<jats:sub>2<\/jats:sub>Cl does not avert magnesium loss, and has less prominent alkalinizing and citraturic effects than the older preparation.<\/jats:p>","DOI":"10.1177\/009127009803801108","type":"journal-article","created":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T00:52:18Z","timestamp":1182473538000},"page":"1035-1041","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of Varying Molar Ratios of Potassium\u2010Magnesium Citrate on Thiazide\u2010Induced Hypokalemia and Magnesium Loss"],"prefix":"10.1002","volume":"38","author":[{"given":"Lisa A.","family":"Ruml","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa\u2010Ann","family":"Wuermser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Poindexter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles Y. C.","family":"Pak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"283","article-title":"Physicochemical action of potassium\u2010magnesium citrate in nephrolithiasis","volume":"7","author":"Pak CYC","year":"1992","journal-title":"J Bone Miner Res"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)68155-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38330-1"},{"key":"e_1_2_1_5_2","first-page":"253","article-title":"The relationship between disorders of K+ and Mg++ homeostasis","volume":"7","author":"Solomon R","year":"1987","journal-title":"Semin Nephrol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-2-396"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F009127009803801108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/009127009803801108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T15:37:44Z","timestamp":1698507464000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/009127009803801108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,11]]},"references-count":5,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1998,11]]}},"alternative-id":["10.1177\/009127009803801108"],"URL":"https:\/\/doi.org\/10.1177\/009127009803801108","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,11]]}}}