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To model assay variability, they added random \u201cnoise\u201d to calculated tracer serum levels. They then fitted those altered levels to the dosing pattern most likely to have produced them, given known kinetics of the tracers. The large number of possible dosing patterns over a month (268,435,456) magnified uncertainty in interpreting noise\u2010altered levels. At best, with an assay variability of 5%, compliance could be estimated only within 4 to 8 doses per month. The tracer with a half\u2010life of 30 days performed best. Pairing tracers did not improve uncertainty. 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