{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T11:58:38Z","timestamp":1698580718309},"reference-count":7,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":4846,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:p><jats:italic>Azimilide dihydrochloride (NE\u201010064) is a novel class III antiarrhythmic agent that blocks both the slowly and rapidly acting components of the delayed rectifier potassium current of human atrial and ventricular myocytes. In clinical studies, azimilide reduced the frequency of symptomatic episodes of atrial fibrillation, atrial flutter, and paroxysmal supraventricular tachycardia. This study was conducted to characterize azimilide pharmacokinetics following single\u2010dose administration of a 1 mg\/kg intravenous infusion (18 min), 2 mg\/kg oral solution, and a 150 mg orally administered capsule. This was a three\u2010period, randomized, crossover study in 27 healthy, drug\u2010free (including caffeine and alcohol), nonsmoking male volunteers (mean [<\/jats:italic>SD<jats:italic>]; age, 25.9 [1.0] years; weight 74.3 [0.7] kg; 23 Caucasians and 4 Hispanics). Blood and urine samples were collected for 2 7 days and analyzed for azimilide using HPLC with UV detection. Subjects were monitored for adverse events and abnormalities in clinical laboratory tests, vital signs, and electrocardiography (including Holter monitoring). Mean (%CV) azimilide parameters were total clearance = 0.143 L\/h\/kg (38%), renal clearance = 0.014 L\/h\/kg (35%), steady\u2010state volume of distribution = 13.2 L\/kg(23%), and terminal exponential half\u2010life = 78.8h (44%). Similar parameter estimates were obtained following oral administration. Both the oral solution and capsule formulations were completely absorbed. In addition, the rate (C<jats:sub>max<\/jats:sub>) and extent of absorption (AUC) following oral administration of the capsule dosage form were bioequivalent to the oral solution with means for times of maximum blood concentration of 7.08 and 7.18 hours for the oral solution and capsule, respectively. Azimilide dihydrochloride was generally well tolerated in all subjects<\/jats:italic>.<\/jats:p>","DOI":"10.1177\/00912709922012088","type":"journal-article","created":{"date-parts":[[2003,7,19]],"date-time":"2003-07-19T09:38:13Z","timestamp":1058607493000},"page":"1272-1276","source":"Crossref","is-referenced-by-count":8,"title":["Azimilide Pharmacokinetics following Intravenous and Oral Administration of a Solution and Capsule Formulation"],"prefix":"10.1002","volume":"39","author":[{"given":"Alfred E.","family":"Corey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Agnew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne N.","family":"Valentine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Nesbitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan L.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary A.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1","article-title":"Azimilide (NE\u201010064) blocks outward K+ currents in human atrial and ventricular myocytes","volume":"92","author":"Lamorgese M","year":"1995","journal-title":"Circulation"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1997.tb04269.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1201\/b14095"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01068419"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01065191"},{"key":"e_1_2_1_7_2","first-page":"53","volume-title":"The Effect of Disease States on Drug Pharmacokinetics","author":"Rowland M","year":"1976"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00710-8"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F00912709922012088","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/00912709922012088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T18:53:14Z","timestamp":1698519194000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/00912709922012088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":7,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["10.1177\/00912709922012088"],"URL":"https:\/\/doi.org\/10.1177\/00912709922012088","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}