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The unique context of clinical trial enrollment grants this research an opportunity to study the RISP model in relation to a risk issue with varying relevance to the two samples as well as to investigate the role of emotion on information seeking. Key results suggested that risk perception and negative emotions had opposite effects on information seeking across the two samples; however, optimistic feelings had the most consistent, positive effects on seeking from all three types of information sources: interpersonal, traditional media, and online. 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