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GI allergic manifestations can be classified as immunoglobulin E (IgE) mediated (immediate GI hypersensitivity and oral allergy syndrome); \u201cmixed\u201d GI allergy syndromes (involving some IgE components and some non\u2010IgE or T\u2010cell\u2010mediated components) include eosinophilic esophagitis and eosinophilic gastroenteritis. Non\u2010IgE\u2010mediated or T\u2010cell\u2010mediated allergic GI disorders include dietary protein enteropathy, protein\u2010induced enterocolitis, and proctitis. All these conditions share a common denominator: the response of the immune system to a specific protein leading to pathologic inflammatory changes in the GI tract. This immunological response can elicit symptoms such as diarrhea, vomiting, dysphagia, constipation, or GI blood loss, symptoms consistent with a GI disorder. The detection of food allergies can be accomplished by the use of radioallergosorbent (RAST) testing and skin prick tests in helping to assess the IgE\u2010mediated disorders. Patch tests may help evaluate delayed hypersensitivity reactions. Treatment of GI allergic disorders ranges from strict dietary elimination of offending food(s), use of protein hydrolysates, and use of <jats:sc>l<\/jats:sc>\u2010amino acid\u2013based formula when protein hydrolysates fail. Treatment with topical (for eosinophilic esophagitis) or systemic steroids is used if all dietary measures are unsuccessful. Maternal breast feeding or the use from birth of hydrolysate formulas (extensive or partial hydrolysates) may be efficacious in the prevention of atopic disease in \u201chigh\u2010risk\u201d families (with at least 1 parent or sibling with a history of atopic disease).<\/jats:p>","DOI":"10.1177\/0115426505020005526","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:23:41Z","timestamp":1210793021000},"page":"526-535","source":"Crossref","is-referenced-by-count":28,"title":["Gastrointestinal Manifestations of Food Allergies in Pediatric Patients"],"prefix":"10.1002","volume":"20","author":[{"given":"Manuel","family":"Garcia\u2010Careaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John 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