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Patients and their family caregivers must balance the positive aspects of being in the home environment with the challenges of administering complex therapies at home. Patients and caregivers need additional support to reduce the physical, emotional, social, and financial burdens they experience. <jats:italic>Conclusions:<\/jats:italic> More research is needed to address effective interventions to reduce patient and caregiver burdens and to improve outcomes for technology\u2010dependent individuals. 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