{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T20:35:41Z","timestamp":1768250141434,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1992,8,1]],"date-time":"1992-08-01T00:00:00Z","timestamp":712627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[1992,8]]},"abstract":"<jats:p>Although selenium is an essential trace element, it is often not routinely added to total parenteral nutrition (TPN) formulations. When selenium is not added, patients are at risk for selenium deficiency. This report describes such a patient. He had several operations for colon cancer, including a massive resection of the small bowel that resulted in a short bowel and a fistula. TPN was started after his last operation. After he was discharged, he had a normal, active lifestyle, except that he limited oral intake to water and an occasional soft drink. After 3 years of almost exclusive nourishment by TPN, he developed whitened nail beds. Investigation for possible trace element deficiency resulted in a finding that he had very low levels of selenium in his blood. He did not have any of the cardiac or skeletal muscle abnormalities that have been associated with selenium deficiency. After supplementation with selenium, his blood levels of selenium rose and the nail bed changes were reversed.<\/jats:p>","DOI":"10.1177\/0115426592007004175","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:23:41Z","timestamp":1210793021000},"page":"175-178","source":"Crossref","is-referenced-by-count":14,"title":["Selenium Deficiency in Long\u2010Term Total Parenteral Nutrition"],"prefix":"10.1002","volume":"7","author":[{"given":"C.K.","family":"Abrams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.M.","family":"Siram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Galsim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Johnson\u2010Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.L.","family":"Munford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mezghebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1093\/ajcn\/31.5.850","article-title":"Selenium content of commercial formula diets","volume":"31","author":"Zabel NL","year":"1978","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199004000-00020"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080240"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1093\/ajcn\/32.10.2076","article-title":"Selenium deficiency in total parenteral nutrition","volume":"32","author":"vanRij AM","year":"1979","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198105143042005"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80247-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/ajcn\/37.2.319","article-title":"Manifestations of chronic selenium deficiency in a child receiving total parenteral nutrition","volume":"37","author":"Kien CL","year":"1983","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac60233a025"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250170"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(54)92717-8"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/ajcn\/38.5.713","article-title":"Selenium and acute alcoholism","volume":"38","author":"Dutta SK","year":"1983","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198010163031622"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01299808"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(82)96790-X"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(83)90250-2"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2660743"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01569a087"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1096\/fasebj.2.14.3181654","article-title":"Blood selenium and glutathione peroxidase activity of populations in New Zealand, Oregon, and South Dakota","volume":"2","author":"Whanger PD","year":"1988","journal-title":"FASEB J"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1996.83"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00644785"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1093\/jn\/119.9.1318","article-title":"Biochemical studies of a selenium deficient population in China. 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