{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:31:36Z","timestamp":1761006696589,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1995,2,1]],"date-time":"1995-02-01T00:00:00Z","timestamp":791596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[1995,2]]},"abstract":"<jats:p>Veno\u2010occlusive disease of the liver is a common complication following the administration of conditioning regimens to patients undergoing bone marrow transplantation. Free\u2010radical damage to the liver is believed to be the cause of the hepatic outflow occlusion, and maintenance of adequate antioxidant stores of glutathione and vitamin E may be a means of counteracting the hepatotoxicity. We report the case of a 44\u2010year\u2010old woman who developed severe veno\u2010occlusive disease after bone marrow transplantation and was treated with vitamin E, the major antioxidant of the cell membrane, and glutamine, a precursor of glutathione. The administration of this therapy was associated with reversal of the clinical and biochemical signs of severe hepatic dysfunction.<\/jats:p>","DOI":"10.1177\/011542659501000116","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:23:41Z","timestamp":1210793021000},"page":"16-18","source":"Crossref","is-referenced-by-count":27,"title":["Use of Vitamin E and Glutamine in the Successful Treatment of Severe Veno\u2010Occlusive Disease Following Bone Marrow Transplantation"],"prefix":"10.1002","volume":"10","author":[{"given":"Thomas V.","family":"Nattakom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Charlton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas W.","family":"Wilmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040578"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198712000-00011"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90266-4"},{"issue":"2","key":"e_1_2_1_5_1","first-page":"894a","article-title":"Agents causing hepatic veno\u2010occlusive disease (HVOD) selectively kill sinusoidal endothelial cells (SECs): common mechanism through GSH depletion [Abstract]","volume":"104","author":"DeLeve LD","year":"1993","journal-title":"Gastroenterology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(93)90023-W"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1182\/blood.V80.10.2458.2458","article-title":"Recombinant human tissue plasminogen activator for the treatment of established severe veno\u2010occlusive disease of the liver after bone marrow transplantation","volume":"80","author":"Bearman SI","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19881001)62:7<1275::AID-CNCR2820620705>3.0.CO;2-I"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199202000-00004"},{"key":"e_1_2_1_10_1","first-page":"756","article-title":"Erythrocyte glutathione. 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In vitro incorporation of radioactive amino acid precursors into the glutathione of human erythrocytes","volume":"60","author":"Miller A.","year":"1962","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(86)90245-X"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(73)90226-1"},{"key":"e_1_2_1_13_1","first-page":"645","volume-title":"Glutathione","author":"Taniguchi M.","year":"1989"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.10.4932"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1139\/o79-029"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2863(93)90058-5"},{"issue":"4","key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"1050S","DOI":"10.1093\/ajcn\/53.4.1050S","article-title":"Protective role of vitamin E in biological systems","volume":"53","author":"Packer L.","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/ajcn\/44.6.973","article-title":"Interpretation of requirements for thiamine, riboflavin, niacin\u2010tryptophan, and vitamin E plus comments on balance studies and vitamin B6","volume":"44","author":"Horwitt MK","year":"1986","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_19_1","first-page":"122","article-title":"What is optimal nutritional support","volume":"2","author":"DeBiasse MA","year":"1994","journal-title":"New Horizons"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/011542659501000116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:50:03Z","timestamp":1760953803000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/011542659501000116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,2]]}},"alternative-id":["10.1177\/011542659501000116"],"URL":"https:\/\/doi.org\/10.1177\/011542659501000116","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"type":"print","value":"0884-5336"},{"type":"electronic","value":"1941-2452"}],"subject":[],"published":{"date-parts":[[1995,2]]}}}