{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:33:53Z","timestamp":1761006833525,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1996,6,1]],"date-time":"1996-06-01T00:00:00Z","timestamp":833587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[1996,6]]},"abstract":"<jats:p>A 43\u2010year\u2010old patient with adult respiratory distress syndrome, alcoholic hallucinosis, and delirium required significant amounts of lorazepam, morphine, and midazolam for management of agitation and increased peak airway pressures. Broad\u2010spectrum antibiotics and intermittent pancuronium therapy were instituted. A nasoenteral feeding tube was placed for nutrition and medication administration during mechanical ventilation. Tube feedings were well tolerated except for intermittent bouts of large amounts of diarrhea. <jats:italic>Clostridium difficile<\/jats:italic> culture and toxin results were negative. Lorazepam and morphine administration were converted from the IV to enteral route to decrease the amount of fluid administered. The tube feeding was changed to an electrolyte rehydration solution and eventually discontinued. A search for drug\u2010related contributing factors to the diarrhea revealed polyethylene glycol present in the lorazepam solution. It was postulated that this could be a contributing cause to the diarrhea. The lorazepam solution was changed to enterally administered crushed tablets with subsequent resolution of diarrhea.<\/jats:p>","DOI":"10.1177\/0115426596011003117","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:23:41Z","timestamp":1210793021000},"page":"117-120","source":"Crossref","is-referenced-by-count":6,"title":["Diarrhea Associated With Lorazepam Solution in a Tube\u2010Fed Patient"],"prefix":"10.1002","volume":"11","author":[{"given":"Michele F.","family":"Shepherd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Felt\u2010Gunderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1996,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90454-L"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607191015003332"},{"key":"e_1_2_1_4_1","first-page":"574","volume-title":"Pharmacotherapy: a pathophysiologic approach","author":"Longe RL","year":"1992"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809302700301"},{"key":"e_1_2_1_6_1","first-page":"247","article-title":"In vitro comparison of the neuromuscular antinicotinic and intestinal antimuscarinic effects of different nondepolarizing muscle relaxants","volume":"299","author":"T\u00f6r\u00f6csik A.","year":"1989","journal-title":"Arch Int Pharmacodyn"},{"key":"e_1_2_1_7_1","first-page":"39","article-title":"Einflu\u00df von pancuroniumbromid auf spontanmotilit\u00e4t des hundedarms (Influence of pancuronium bromide on spontaneous intestinal motility in the dog)","volume":"31","author":"Wiedemann K.","year":"1982","journal-title":"Anaesthesist"},{"key":"e_1_2_1_8_1","first-page":"821","article-title":"Pancuronium and abnormal abdominal roentgenograms","volume":"134","author":"Dillard RG","year":"1980","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_9_1","first-page":"414","article-title":"Whole\u2010bowel irrigation for mechanical colon cleansing","volume":"4","author":"Michael KA","year":"1985","journal-title":"Clin Pharm"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0016-5085(80)90781-7","article-title":"Development of a lavage solution associated with minimal water and electrolyte absorption or secretion","volume":"78","author":"Davis GR","year":"1980","journal-title":"Gastroenterology"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70371-3"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198912000-00010"},{"key":"e_1_2_1_13_1","first-page":"387","article-title":"Pink\u201d diarrhea: osmotic diarrhea from a sorbitol\u2010containing vitamin C supplement","volume":"1","author":"Hill RE","year":"1982","journal-title":"Med J Aust"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80563-X"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0115426596011003117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:14:26Z","timestamp":1760955266000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0115426596011003117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,6]]}},"alternative-id":["10.1177\/0115426596011003117"],"URL":"https:\/\/doi.org\/10.1177\/0115426596011003117","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"type":"print","value":"0884-5336"},{"type":"electronic","value":"1941-2452"}],"subject":[],"published":{"date-parts":[[1996,6]]}}}