{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:29:02Z","timestamp":1790202542315,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Soc Med"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p>Osteomalacia is not rare in the UK and climatically similar countries, particularly in elderly people and those of Asian descent. Overt clinical osteomalacia is usually treated with a loading dose of vitamin D, followed by a regular supplement. However, little is known of the time taken to reach a stable biochemical state after starting treatment. Such information would shed light on the duration of the bone remineralization phase and guide decisions on the length of follow-up. To address this we conducted a 2-year follow-up study of 42 patients (35 female, mean age 80.8 years) with biopsy proven osteomalacia treated with a standard replacement regimen and general nutritional support.<\/jats:p>\n                  <jats:p>Although normocalcaemia was attained within 4 weeks the mean values continued to rise, to a mid-range plateau at 52 weeks. The phosphate and alkaline phosphatase values also took at least a year to reach a stable mean, with a slight further trend towards the mid-range for the entire 104 weeks. The mean serum albumin also rose throughout the first 52 weeks, indicating an effective response to the general nutritional support measures.<\/jats:p>\n                  <jats:p>Our observations suggest that the dynamic relationship between calcium, phosphate and bone requires at least a year, and probably longer, to reach an equilibrium after treatment for osteomalacia in elderly patients. The findings emphasize the need for close medical and social follow-up in this clinical context.<\/jats:p>","DOI":"10.1177\/014107680409701104","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T03:57:58Z","timestamp":1511409478000},"page":"527-530","source":"Crossref","is-referenced-by-count":15,"title":["Biochemical Recovery Time Scales in Elderly Patients with Osteomalacia"],"prefix":"10.1177","volume":"97","author":[{"given":"S C","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Medicine and Geriatrics, Royal Bournemouth Hospital, Castle Lane East, Bournemouth BH7 7DW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Raut","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics, Royal Bournemouth Hospital, Castle Lane East, Bournemouth BH7 7DW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,11,1]]},"reference":[{"key":"bibr1-014107680409701104","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/16.1.35"},{"key":"bibr2-014107680409701104","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90682-2"},{"key":"bibr3-014107680409701104","first-page":"530","volume":"6","author":"Bell N.H.","year":"1997","journal-title":"Curr Ther Endocrinol Metab"},{"key":"bibr4-014107680409701104","first-page":"145","volume":"11","author":"Francis R.M.","year":"1997","journal-title":"Clin Endocrinol Metab"},{"key":"bibr5-014107680409701104","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/24.2.103"},{"key":"bibr6-014107680409701104","doi-asserted-by":"publisher","DOI":"10.1159\/000071707"},{"key":"bibr7-014107680409701104","doi-asserted-by":"publisher","DOI":"10.4065\/78.12.1463"},{"key":"bibr8-014107680409701104","first-page":"133","volume":"33","author":"Nowson C.A.","year":"2004","journal-title":"Aust Fam Physician"},{"key":"bibr9-014107680409701104","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/20.2.132"},{"key":"bibr10-014107680409701104","doi-asserted-by":"publisher","DOI":"10.1016\/0169-6009(90)90063-L"},{"key":"bibr11-014107680409701104","doi-asserted-by":"publisher","DOI":"10.1177\/014107680409700704"},{"key":"bibr12-014107680409701104","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.72B6.2123201"},{"key":"bibr13-014107680409701104","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212033272305"},{"key":"bibr14-014107680409701104","first-page":"U536","volume":"116","author":"Wu F.","year":"2003","journal-title":"NZ J Med"},{"key":"bibr15-014107680409701104","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/16.3.178"},{"key":"bibr16-014107680409701104","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112253"},{"key":"bibr17-014107680409701104","first-page":"406","volume":"6","author":"Simon J.","year":"2002","journal-title":"J Nutr Health Aging"},{"key":"bibr18-014107680409701104","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015263514765"}],"container-title":["Journal of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107680409701104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107680409701104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:51:16Z","timestamp":1777528276000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014107680409701104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":18,"aliases":["10.1258\/jrsm.97.11.527"],"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1177\/014107680409701104"],"URL":"https:\/\/doi.org\/10.1177\/014107680409701104","relation":{},"ISSN":["0141-0768","1758-1095"],"issn-type":[{"value":"0141-0768","type":"print"},{"value":"1758-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}