{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:50:19Z","timestamp":1778277019268,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1980,4,1]],"date-time":"1980-04-01T00:00:00Z","timestamp":323395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Soc Med"],"published-print":{"date-parts":[[1980,4]]},"abstract":"<jats:p>Hypertonic saline was infused into 11 volunteers to osmotically stimulate vasopressin secretion. A strong positive correlation between plasma arginine vasopressin (PAVP) and plasma osmolality (Pos) was obtained, defined by the function PAVP = 0.63 (Pos \u2013 284), r = +0.80, P &lt; 0.001. The sensitivity of vasopressin secretion to osmotic stimulation was represented by the slope of the expression and the theoretical threshold of vasopressin release by the abscissal intercept. Plasma osmolality at the onset of thirst was 298.5 \u00b1 1.1 mmol\/kg. Application of hypertonic saline infusion to 10 polyuric patients clearly separated those with normal osmoregulation of vasopressin secretion from those with cranial diabetes insipidus.<\/jats:p>","DOI":"10.1177\/014107688007300408","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:48:45Z","timestamp":1520470125000},"page":"255-260","source":"Crossref","is-referenced-by-count":92,"title":["Plasma Vasopressin Response to Hypertonic Saline Infusion to Assess Posterior Pituitary Function"],"prefix":"10.1177","volume":"73","author":[{"given":"P H","family":"Baylis","sequence":"first","affiliation":[{"name":"Department of Medicine, Indiana University Medical Center and VA Hospital, Indianapolis, Indiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G L","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University Medical Center and VA Hospital, Indianapolis, Indiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1980,4,1]]},"reference":[{"key":"bibr1-014107688007300408","first-page":"235","volume":"28","author":"Barlow E.D.","year":"1959","journal-title":"Quarterly Journal of Medicine"},{"key":"bibr2-014107688007300408","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90610-9"},{"key":"bibr3-014107688007300408","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109184"},{"key":"bibr4-014107688007300408","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-7-11-753"},{"key":"bibr5-014107688007300408","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1963.03060090031011"},{"key":"bibr6-014107688007300408","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107521"},{"key":"bibr7-014107688007300408","first-page":"1132","volume":"27","author":"Gauer O.H.","year":"1968","journal-title":"Federation Proceedings"},{"key":"bibr8-014107688007300408","first-page":"F100","volume":"237","author":"Gellai M.","year":"1979","journal-title":"American Journal of Physiology"},{"key":"bibr9-014107688007300408","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101549"},{"key":"bibr10-014107688007300408","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1970.218.5.1273"},{"key":"bibr11-014107688007300408","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-73-5-721"},{"key":"bibr12-014107688007300408","first-page":"333","volume":"33","author":"Robertson G.L.","year":"1977","journal-title":"Recent Progress in Hormone Research"},{"key":"bibr13-014107688007300408","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-42-4-613"},{"key":"bibr14-014107688007300408","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107423"},{"key":"bibr15-014107688007300408","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1976.76"},{"key":"bibr16-014107688007300408","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1938.sp000757"},{"key":"bibr17-014107688007300408","first-page":"531A","volume":"24","author":"Shelton R.L.","year":"1976","journal-title":"Clinical Research"},{"key":"bibr18-014107688007300408","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1947.0037"},{"key":"bibr19-014107688007300408","first-page":"606A","volume":"25","author":"Zerbe R.","year":"1977","journal-title":"Clinical Research"}],"container-title":["Journal of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107688007300408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107688007300408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:36:42Z","timestamp":1777527402000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014107688007300408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1980,4]]}},"alternative-id":["10.1177\/014107688007300408"],"URL":"https:\/\/doi.org\/10.1177\/014107688007300408","relation":{},"ISSN":["0141-0768","1758-1095"],"issn-type":[{"value":"0141-0768","type":"print"},{"value":"1758-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,4]]}}}