{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:11:21Z","timestamp":1777864281023,"version":"3.51.4"},"reference-count":3,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1981,4,1]],"date-time":"1981-04-01T00:00:00Z","timestamp":354931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Soc Med"],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:p>The powerful peripheral vasodilator minoxidil, in a dose of 5-40 mg daily, controlled the previously refractory blood pressure in 45 out of 47 patients for periods up to fifty-seven months. The majority of the previous polypharmacy was withdrawn, leaving most of the patients taking a beta-blocking drug, minoxidil and a diuretic. Severe sodium retention leading to congestive cardiac failure necessitated the withdrawal of the drug in 3 patients. In one patient the drug was discontinued because of postural hypotension, and it was withdrawn in 2 female patients because of hirsutism. Five patients were removed from the trial as they were started on chronic maintenance haemodialysis or received a renal transplant. Significant glucose intolerance developed in one patient, requiring the addition of an oral hypoglycaemic agent. The 4 deaths that occurred were not directly related to treatment. Following the oral administration of 5 mg minoxidil, an obvious reduction in both the systolic and diastolic pressure was seen in two hours.<\/jats:p>","DOI":"10.1177\/014107688107400408","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T01:22:23Z","timestamp":1519780943000},"page":"278-282","source":"Crossref","is-referenced-by-count":6,"title":["Clinical use of Minoxidil (Loniten)"],"prefix":"10.1177","volume":"74","author":[{"given":"A M","family":"Joekes","sequence":"first","affiliation":[{"name":"St Peter's Group of Hospitals and Institute of Urology, London WC2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F D","family":"Thompson","sequence":"additional","affiliation":[{"name":"St Peter's Group of Hospitals and Institute of Urology, London WC2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P F B","family":"O'Regan","sequence":"additional","affiliation":[{"name":"St Peter's Group of Hospitals and Institute of Urology, London WC2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1981,4,1]]},"reference":[{"key":"bibr1-014107688107400408","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0022-3565(25)29457-5","volume":"184","author":"DuCharme D.W.","year":"1973","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"bibr2-014107688107400408","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1972133436"},{"key":"bibr3-014107688107400408","first-page":"97s","volume":"48","author":"Prichard B.N.C.","year":"1975","journal-title":"Clinical Science and Molecular Medicine"}],"container-title":["Journal of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107688107400408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107688107400408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:39:24Z","timestamp":1777527564000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014107688107400408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4]]},"references-count":3,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,4]]}},"alternative-id":["10.1177\/014107688107400408"],"URL":"https:\/\/doi.org\/10.1177\/014107688107400408","relation":{},"ISSN":["0141-0768","1758-1095"],"issn-type":[{"value":"0141-0768","type":"print"},{"value":"1758-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,4]]}}}