{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:14:15Z","timestamp":1777864455047,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1982,9,1]],"date-time":"1982-09-01T00:00:00Z","timestamp":399686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Soc Med"],"published-print":{"date-parts":[[1982,9]]},"abstract":"<jats:p>The synchronous relationship between oestrogen (ER) and progesterone (PgR) receptor status in primary tumours and their nodal metastases has been analysed in 26 patients. All patients with ER-negative primary tumours were found to have ER-negative axillary nodes but of those with ER-positive tumours only 65% had, correspondingly, all nodes ER-positive. The concentration of ER in the nodes was found to be significantly lower ( P &lt; 0.001) than that in the primary tumour. PgR information was unobtainable in 3 patients. Of the remainder, 75% of those having PgR-negative tumours had all nodes PgR-negative but only 36% of those with PgR-positive tumours had all nodes PgR-positive. PgR levels were found to be generally lower in the axillary nodes but this did not reach statistical significance. The clinical relevance of these findings is discussed.<\/jats:p>","DOI":"10.1177\/014107688207500909","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T06:49:17Z","timestamp":1657176557000},"page":"719-722","source":"Crossref","is-referenced-by-count":5,"title":["Variability of Oestrogen and Progesterone Receptor Status between Primary Breast Cancer and Nodal Metastases: Preliminary Communication"],"prefix":"10.1177","volume":"75","author":[{"given":"Dolores","family":"Fernandez","sequence":"first","affiliation":[{"name":"Charing Cross Hospital, Fulham Palace Road, London W6 8RF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamshid","family":"Alaghband-Zadeh","sequence":"additional","affiliation":[{"name":"Charing Cross Hospital, Fulham Palace Road, London W6 8RF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Sauven","sequence":"additional","affiliation":[{"name":"Charing Cross Hospital, Fulham Palace Road, London W6 8RF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Ian","family":"Burn","sequence":"additional","affiliation":[{"name":"Charing Cross Hospital, Fulham Palace Road, London W6 8RF"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1982,9,1]]},"reference":[{"key":"bibr1-014107688207500909","first-page":"796","author":"Beatson G T","year":"1896","journal-title":"Lancet"},{"key":"bibr2-014107688207500909","first-page":"260","volume":"137","author":"Brennan M J","year":"1979","journal-title":"American Journal of Cancer"},{"key":"bibr3-014107688207500909","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930090610"},{"key":"bibr4-014107688207500909","first-page":"5","volume":"8","author":"Hahnel R","year":"1981","journal-title":"Reviews on endocrine-related cancer"},{"key":"bibr5-014107688207500909","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197907000-00015"},{"key":"bibr6-014107688207500909","first-page":"3362","volume":"35","author":"Jensen E V","year":"1975","journal-title":"Cancer Research"},{"key":"bibr7-014107688207500909","first-page":"55","volume":"34","author":"Jensen E V","year":"1971","journal-title":"National Cancer Institute Monographs"},{"key":"bibr8-014107688207500909","volume-title":"Steroid Receptor Assays in Human Breast Tumours\u2013methodological and clinical aspects","author":"King R J B","year":"1979"},{"key":"bibr9-014107688207500909","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5951.185"},{"key":"bibr10-014107688207500909","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197706)39:6<2934::AID-CNCR2820390680>3.0.CO;2-P"},{"key":"bibr11-014107688207500909","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197601000-00017"},{"key":"bibr12-014107688207500909","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(78)90289-1"}],"container-title":["Journal of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107688207500909","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107688207500909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:42:11Z","timestamp":1777527731000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014107688207500909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,9]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1982,9]]}},"alternative-id":["10.1177\/014107688207500909"],"URL":"https:\/\/doi.org\/10.1177\/014107688207500909","relation":{},"ISSN":["0141-0768","1758-1095"],"issn-type":[{"value":"0141-0768","type":"print"},{"value":"1758-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,9]]}}}