{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:14:34Z","timestamp":1777864474651,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1983,10,1]],"date-time":"1983-10-01T00:00:00Z","timestamp":433814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Soc Med"],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:p>Pigs and other farm animals are usually transported at least once during their lives; for example, all meat animals are finally taken to the abattoir for slaughter. The vibration, noise and handling associated with such transportation is usually novel to the animals, and therefore constitutes a potential \u2018stressor\u2019. Such adverse stimuli may trigger physiological and psychological changes which rapidly produce profound changes in blood flow to peripheral organs, particularly the kidney, whose blood vessels are richly supplied with sympathetic nerve fibres. In the present study, ultrasonic techniques have been used with chronically implanted flow sensors for measuring heart rate (HR) and changes in renal blood flow (RBF) in conscious, freestanding and unanaesthetized pigs to monitor their cardiovascular responses to vibration, noise and various handling procedures. In addition, arterial blood pressure (BP) was measured via a catheter placed in the carotid artery. To ensure that vibration and noise could be accurately reproduced, a transport simulator (TS) was constructed in the laboratory.<\/jats:p>\n                  <jats:p>A small decrease of approximately 5% was observed in RBF during the first few minutes of exposure to vibration and noise, but this returned to the control levels monitored in undisturbed animals within a few minutes. Thereafter, RBF became significantly elevated for the remaining period of exposure to vibration and noise. In contrast, HR remained significantly increased throughout. BP was not significantly changed as a result of the experimental manipulation. Restraint and handling of the animals appeared to cause maximal disturbance. HR and BP were more than doubled compared with the resting value, but there was a concomitant marked decrease in RBF. For example, in one pig, the normal renal blood flow of 5 ml\/s was reduced to nearly half during the handling procedure. This, however, returned to normal levels within 4 min of release.<\/jats:p>","DOI":"10.1177\/014107688307601008","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T01:33:39Z","timestamp":1519781619000},"page":"841-847","source":"Crossref","is-referenced-by-count":19,"title":["Effects of Vibration, Noise and Restraint on Heart Rate, Blood Pressure and Renal Blood Flow in the Pig"],"prefix":"10.1177","volume":"76","author":[{"given":"D B","family":"Stephens","sequence":"first","affiliation":[{"name":"ARC Institute of Animal Physiology, Babraham, Cambridge CB2 4AT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R D","family":"Rader","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics University of Southern California, Los Angeles, California 90007, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1983,10,1]]},"reference":[{"key":"bibr1-014107688307601008","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0022-3565(25)26864-1","volume":"145","author":"Anton A.H.","year":"1964","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"bibr2-014107688307601008","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-197605000-00004"},{"key":"bibr3-014107688307601008","doi-asserted-by":"publisher","DOI":"10.1007\/BF03000292"},{"key":"bibr4-014107688307601008","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(73)90309-0"},{"key":"bibr5-014107688307601008","first-page":"17","volume":"54","author":"Bell C.","year":"1978","journal-title":"Clinical Science and Molecular Medicine"},{"key":"bibr6-014107688307601008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1953.tb00949.x"},{"key":"bibr7-014107688307601008","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-195609000-00006"},{"key":"bibr8-014107688307601008","unstructured":"BrodJ. 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