{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:14:33Z","timestamp":1777864473952,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[1986,8,1]],"date-time":"1986-08-01T00:00:00Z","timestamp":523238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Soc Med"],"published-print":{"date-parts":[[1986,8]]},"abstract":"<jats:p>Forty-eight hirsute women were treated with spironolactone 100 mg twice daily for 3 to 12 months. Both facial and body hirsuties improved by 30\u201340%, and there was a threefold reduction in frequency of local treatments such as waxing or shaving. Plasma testosterone fell by 30%, though the improvement in hirsuties grading did not correlate with the fall in plasma testosterone. Six subjects discontinued treatment because of lack of effect, and 4 because of menstrual disturbance. Spironolactone was equally effective in the treatment of idiopathic hirsutism and of the polycystic ovary syndrome.<\/jats:p>","DOI":"10.1177\/014107688607900806","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T20:12:13Z","timestamp":1484251933000},"page":"451-453","source":"Crossref","is-referenced-by-count":18,"title":["Spironolactone in the Treatment of Idiopathic Hirsutism and the Polycystic Ovary Syndrome"],"prefix":"10.1177","volume":"79","author":[{"given":"D J","family":"Evans","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Radcliffe Infirmary, Oxford"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C W","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Radcliffe Infirmary, Oxford"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,8,1]]},"reference":[{"key":"bibr-bibr1-014107688607900806","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)48189-6"},{"key":"bibr-bibr2-014107688607900806","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-5-630"},{"key":"bibr-bibr3-014107688607900806","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-5-643"},{"key":"bibr-bibr4-014107688607900806","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)44232-9"},{"key":"bibr-bibr5-014107688607900806","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-51-3-429"},{"key":"bibr-bibr6-014107688607900806","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320340049034"},{"key":"bibr-bibr7-014107688607900806","first-page":"429","volume":"61","author":"Milewicz A","year":"1983","journal-title":"Obstet Gynecol"},{"key":"bibr-bibr8-014107688607900806","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350556"},{"key":"bibr-bibr9-014107688607900806","first-page":"393","volume":"44","author":"Abramovici Y","year":"1983","journal-title":"Annales d'Endocrinologie (Paris)"},{"key":"bibr-bibr10-014107688607900806","first-page":"49","volume":"11","author":"Spandri P","year":"1984","journal-title":"Clin Exp Obst Gyn"},{"key":"bibr-bibr11-014107688607900806","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)48373-1"},{"key":"bibr-bibr12-014107688607900806","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1985.tb00211.x"},{"key":"bibr-bibr13-014107688607900806","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1973.03220280028007"},{"key":"bibr-bibr14-014107688607900806","doi-asserted-by":"publisher","DOI":"10.1139\/o79-131"},{"key":"bibr-bibr15-014107688607900806","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-59-1-51"},{"key":"bibr-bibr16-014107688607900806","doi-asserted-by":"publisher","DOI":"10.1210\/endo-94-6-1628"}],"container-title":["Journal of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107688607900806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107688607900806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:42:29Z","timestamp":1777527749000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/014107688607900806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1986,8]]}},"alternative-id":["10.1177\/014107688607900806"],"URL":"https:\/\/doi.org\/10.1177\/014107688607900806","relation":{},"ISSN":["0141-0768","1758-1095"],"issn-type":[{"value":"0141-0768","type":"print"},{"value":"1758-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,8]]}}}